WNT5B

From Wikipedia, the free encyclopedia

Wingless-type MMTV integration site family, member 5B

Identifiers

WNT5B; MGC2648

External IDs

OMIM: 606361 MGI: 98959 HomoloGene: 22530

Gene ontology
Molecular Function:	• signal transducer activity • protein binding
Cellular Component:	• extracellular region
Biological Process:	• Wnt receptor signaling pathway, calcium modulating pathway • multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_030775 (mRNA)
NP_110402 (protein)

NM_009525 (mRNA)
NP_033551 (protein)

Location

Chr 12: 1.6 - 1.63 Mb

Chr 6: 119.4 - 119.51 Mb

Pubmed search

[1]

[2]

Wingless-type MMTV integration site family, member 5B, also known as WNT5B, is a human gene.^[1]

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants.^[1]

[edit] References

^ ^a ^b Entrez Gene: WNT5B wingless-type MMTV integration site family, member 5B.

[edit] Further reading

Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface.". Mol. Biol. Cell 4 (12): 1267–75. PMID 8167409.
Tanaka K, Okabayashi K, Asashima M, et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.". Eur. J. Biochem. 267 (13): 4300–11. PMID 10866835.
Saitoh T, Katoh M (2001). "Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region.". Int. J. Oncol. 19 (2): 347–51. PMID 11445850.
Saitoh T, Katoh M (2003). "Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells.". Int. J. Mol. Med. 10 (3): 345–9. PMID 12165812.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kanazawa A, Tsukada S, Sekine A, et al. (2005). "Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes.". Am. J. Hum. Genet. 75 (5): 832–43. doi:10.1086/425340. PMID 15386214.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Mangioni S, Viganò P, Lattuada D, et al. (2005). "Overexpression of the Wnt5b gene in leiomyoma cells: implications for a role of the Wnt signaling pathway in the uterine benign tumor.". J. Clin. Endocrinol. Metab. 90 (9): 5349–55. doi:10.1210/jc.2005-0272. PMID 15972578.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.