WNT3

From Wikipedia, the free encyclopedia

Wingless-type MMTV integration site family, member 3

Identifiers

WNT3; INT4; MGC131950; MGC138321; MGC138323

External IDs

OMIM: 165330 MGI: 98955 HomoloGene: 22527

Gene ontology
Molecular Function:	• signal transducer activity • extracellular matrix structural constituent • protein binding
Cellular Component:	• extracellular region • proteinaceous extracellular matrix
Biological Process:	• Wnt receptor signaling pathway, calcium modulating pathway • cell-cell signaling • multicellular organismal development • anatomical structure morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_030753 (mRNA)
NP_110380 (protein)

NM_009521 (mRNA)
NP_033547 (protein)

Location

Chr 17: 42.2 - 42.25 Mb

Chr 11: 103.59 - 103.63 Mb

Pubmed search

[1]

[2]

Wingless-type MMTV integration site family, member 3, also known as WNT3, is a human gene.^[1]

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.^[1]

[edit] References

^ ^a ^b Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3.

[edit] Further reading

Nusse R, Brown A, Papkoff J, et al. (1991). "A new nomenclature for int-1 and related genes: the Wnt gene family.". Cell 64 (2): 231. PMID 1846319.
Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface.". Mol. Biol. Cell 4 (12): 1267–75. PMID 8167409.
Roelink H, Wang J, Black DM, et al. (1993). "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene.". Genomics 17 (3): 790–2. doi:10.1006/geno.1993.1412. PMID 8244403.
Liu P, Wakamiya M, Shea MJ, et al. (1999). "Requirement for Wnt3 in vertebrate axis formation.". Nat. Genet. 22 (4): 361–5. doi:10.1038/11932. PMID 10431240.
Gazit A, Yaniv A, Bafico A, et al. (1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.". Oncogene 18 (44): 5959–66. doi:10.1038/sj.onc.1202985. PMID 10557084.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Katoh M (2002). "Molecular cloning and characterization of human WNT3.". Int. J. Oncol. 19 (5): 977–82. PMID 11604997.
Katoh M (2002). "Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45.". Int. J. Oncol. 20 (2): 373–7. PMID 11788904.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Niemann S, Zhao C, Pascu F, et al. (2004). "Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family.". Am. J. Hum. Genet. 74 (3): 558–63. doi:10.1086/382196. PMID 14872406.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Chiba H, Kobune M, Kato J, et al. (2005). "Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells.". Exp. Hematol. 32 (12): 1194–203. doi:10.1016/j.exphem.2004.08.010. PMID 15588944.
Yamamoto H, Komekado H, Kikuchi A (2006). "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.". Dev. Cell 11 (2): 213–23. doi:10.1016/j.devcel.2006.07.003. PMID 16890161.