WNT11

From Wikipedia, the free encyclopedia

Wingless-type MMTV integration site family, member 11

Identifiers

WNT11; HWNT11; MGC141946; MGC141948

External IDs

OMIM: 603699 MGI: 101948 HomoloGene: 20970

Gene ontology
Molecular Function:	• signal transducer activity
Cellular Component:	• extracellular region
Biological Process:	• signal transduction • Wnt receptor signaling pathway, calcium modulating pathway • cell-cell signaling • multicellular organismal development • anatomical structure morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004626 (mRNA)
NP_004617 (protein)

NM_009519 (mRNA)
NP_033545 (protein)

Location

Chr 11: 75.58 - 75.6 Mb

Chr 7: 98.71 - 98.73 Mb

Pubmed search

[1]

[2]

Wingless-type MMTV integration site family, member 11, also known as WNT11, is a human gene.^[1]

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome.^[1]

[edit] References

^ ^a ^b Entrez Gene: WNT11 wingless-type MMTV integration site family, member 11.

[edit] Further reading

Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface.". Mol. Biol. Cell 4 (12): 1267-75. PMID 8167409.
Lako M, Strachan T, Bullen P, et al. (1998). "Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung.". Gene 219 (1-2): 101-10. PMID 9757009.
Kirikoshi H, Sekihara H, Katoh M (2002). "Molecular cloning and characterization of human WNT11.". Int. J. Mol. Med. 8 (6): 651-6. PMID 11712081.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ouko L, Ziegler TR, Gu LH, et al. (2004). "Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells.". J. Biol. Chem. 279 (25): 26707-15. doi:10.1074/jbc.M402877200. PMID 15084607.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kim SW, Park JI, Spring CM, et al. (2005). "Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin.". Nat. Cell Biol. 6 (12): 1212-20. doi:10.1038/ncb1191. PMID 15543138.
Koyanagi M, Haendeler J, Badorff C, et al. (2005). "Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells.". J. Biol. Chem. 280 (17): 16838-42. doi:10.1074/jbc.M500323200. PMID 15701629.
Garriock RJ, D'Agostino SL, Pilcher KC, Krieg PA (2005). "Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus.". Dev. Biol. 279 (1): 179-92. doi:10.1016/j.ydbio.2004.12.013. PMID 15708567.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.