WNK4

From Wikipedia, the free encyclopedia


WNK lysine deficient protein kinase 4
Identifiers
Symbol(s) WNK4; PHA2B; PRKWNK4
External IDs OMIM: 601844 MGI1917097 HomoloGene13020
Orthologs
Human Mouse
Entrez 65266 69847
Ensembl ENSG00000126562 n/a
Uniprot Q96J92 n/a
Refseq NM_032387 (mRNA)
NP_115763 (protein)
NM_175638 (mRNA)
NP_783569 (protein)
Location Chr 17: 38.19 - 38.2 Mb n/a
Pubmed search [1] [2]

WNK lysine deficient protein kinase 4, also known as WNK4, is a human gene.[1]

The WNK4 gene encodes a serine-threonine kinase expressed in distal nephron.[supplied by OMIM][1]

[edit] References

[edit] Further reading

  • Subramanya AR, Yang CL, McCormick JA, Ellison DH (2006). "WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron.". Kidney Int. 70 (4): 630-4. doi:10.1038/sj.ki.5001634. PMID 16820787. 
  • Peng JB, Warnock DG (2007). "WNK4-mediated regulation of renal ion transport proteins.". Am. J. Physiol. Renal Physiol. 293 (4): F961-73. doi:10.1152/ajprenal.00192.2007. PMID 17634397. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548. 
  • Wilson FH, Disse-Nicodème S, Choate KA, et al. (2001). "Human hypertension caused by mutations in WNK kinases.". Science 293 (5532): 1107-12. doi:10.1126/science.1062844. PMID 11498583. 
  • Veríssimo F, Jordan P (2001). "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.". Oncogene 20 (39): 5562-9. doi:10.1038/sj.onc.1204726. PMID 11571656. 
  • Wilson FH, Kahle KT, Sabath E, et al. (2003). "Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4.". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 680-4. doi:10.1073/pnas.242735399. PMID 12515852. 
  • Erlich PM, Cui J, Chazaro I, et al. (2003). "Genetic variants of WNK4 in whites and African Americans with hypertension.". Hypertension 41 (6): 1191-5. doi:10.1161/01.HYP.0000070025.30572.91. PMID 12719438. 
  • Piechotta K, Garbarini N, England R, Delpire E (2004). "Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase.". J. Biol. Chem. 278 (52): 52848-56. doi:10.1074/jbc.M309436200. PMID 14563843. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Kahle KT, Gimenez I, Hassan H, et al. (2004). "WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia.". Proc. Natl. Acad. Sci. U.S.A. 101 (7): 2064-9. doi:10.1073/pnas.0308434100. PMID 14769928. 
  • Yamauchi K, Rai T, Kobayashi K, et al. (2004). "Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4690-4. doi:10.1073/pnas.0306924101. PMID 15070779. 
  • Kamide K, Takiuchi S, Tanaka C, et al. (2004). "Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes.". Am. J. Hypertens. 17 (5 Pt 1): 446-9. doi:10.1016/j.amjhyper.2003.12.020. PMID 15110905. 
  • Mayan H, Munter G, Shaharabany M, et al. (2004). "Hypercalciuria in familial hyperkalemia and hypertension accompanies hyperkalemia and precedes hypertension: description of a large family with the Q565E WNK4 mutation.". J. Clin. Endocrinol. Metab. 89 (8): 4025-30. doi:10.1210/jc.2004-0037. PMID 15292344. 
  • Fu Y, Subramanya A, Rozansky D, Cohen DM (2006). "WNK kinases influence TRPV4 channel function and localization.". Am. J. Physiol. Renal Physiol. 290 (6): F1305-14. doi:10.1152/ajprenal.00391.2005. PMID 16403833. 
  • Cai H, Cebotaru V, Wang YH, et al. (2006). "WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells.". Kidney Int. 69 (12): 2162-70. doi:10.1038/sj.ki.5000333. PMID 16688122. 
  • Jiang Y, Ferguson WB, Peng JB (2007). "WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4.". Am. J. Physiol. Renal Physiol. 292 (2): F545-54. doi:10.1152/ajprenal.00187.2006. PMID 17018846. 
  • Ring AM, Leng Q, Rinehart J, et al. (2007). "An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis.". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 4025-9. doi:10.1073/pnas.0611728104. PMID 17360471.