WNK4
From Wikipedia, the free encyclopedia
WNK lysine deficient protein kinase 4
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Identifiers | ||||||||||||||
Symbol(s) | WNK4; PHA2B; PRKWNK4 | |||||||||||||
External IDs | OMIM: 601844 MGI: 1917097 HomoloGene: 13020 | |||||||||||||
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Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 65266 | 69847 | ||||||||||||
Ensembl | ENSG00000126562 | n/a | ||||||||||||
Uniprot | Q96J92 | n/a | ||||||||||||
Refseq | NM_032387 (mRNA) NP_115763 (protein) |
NM_175638 (mRNA) NP_783569 (protein) |
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Location | Chr 17: 38.19 - 38.2 Mb | n/a | ||||||||||||
Pubmed search | [1] | [2] |
WNK lysine deficient protein kinase 4, also known as WNK4, is a human gene.[1]
The WNK4 gene encodes a serine-threonine kinase expressed in distal nephron.[supplied by OMIM][1]
[edit] References
[edit] Further reading
- Subramanya AR, Yang CL, McCormick JA, Ellison DH (2006). "WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron.". Kidney Int. 70 (4): 630-4. doi: . PMID 16820787.
- Peng JB, Warnock DG (2007). "WNK4-mediated regulation of renal ion transport proteins.". Am. J. Physiol. Renal Physiol. 293 (4): F961-73. doi: . PMID 17634397.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
- Wilson FH, Disse-Nicodème S, Choate KA, et al. (2001). "Human hypertension caused by mutations in WNK kinases.". Science 293 (5532): 1107-12. doi: . PMID 11498583.
- Veríssimo F, Jordan P (2001). "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.". Oncogene 20 (39): 5562-9. doi: . PMID 11571656.
- Wilson FH, Kahle KT, Sabath E, et al. (2003). "Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4.". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 680-4. doi: . PMID 12515852.
- Erlich PM, Cui J, Chazaro I, et al. (2003). "Genetic variants of WNK4 in whites and African Americans with hypertension.". Hypertension 41 (6): 1191-5. doi: . PMID 12719438.
- Piechotta K, Garbarini N, England R, Delpire E (2004). "Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase.". J. Biol. Chem. 278 (52): 52848-56. doi: . PMID 14563843.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi: . PMID 14702039.
- Kahle KT, Gimenez I, Hassan H, et al. (2004). "WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia.". Proc. Natl. Acad. Sci. U.S.A. 101 (7): 2064-9. doi: . PMID 14769928.
- Yamauchi K, Rai T, Kobayashi K, et al. (2004). "Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4690-4. doi: . PMID 15070779.
- Kamide K, Takiuchi S, Tanaka C, et al. (2004). "Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes.". Am. J. Hypertens. 17 (5 Pt 1): 446-9. doi: . PMID 15110905.
- Mayan H, Munter G, Shaharabany M, et al. (2004). "Hypercalciuria in familial hyperkalemia and hypertension accompanies hyperkalemia and precedes hypertension: description of a large family with the Q565E WNK4 mutation.". J. Clin. Endocrinol. Metab. 89 (8): 4025-30. doi: . PMID 15292344.
- Fu Y, Subramanya A, Rozansky D, Cohen DM (2006). "WNK kinases influence TRPV4 channel function and localization.". Am. J. Physiol. Renal Physiol. 290 (6): F1305-14. doi: . PMID 16403833.
- Cai H, Cebotaru V, Wang YH, et al. (2006). "WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells.". Kidney Int. 69 (12): 2162-70. doi: . PMID 16688122.
- Jiang Y, Ferguson WB, Peng JB (2007). "WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4.". Am. J. Physiol. Renal Physiol. 292 (2): F545-54. doi: . PMID 17018846.
- Ring AM, Leng Q, Rinehart J, et al. (2007). "An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis.". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 4025-9. doi: . PMID 17360471.