WNK2

From Wikipedia, the free encyclopedia

WNK lysine deficient protein kinase 2

Identifiers

WNK2; KIAA1760; NY-CO-43; P/OKcl.13; PRKWNK2; SDCCAG43

External IDs

OMIM: 606249 MGI: 1922857 HomoloGene: 19155

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation • protein kinase cascade

Orthologs

Human

Mouse

n/a

Refseq

NM_006648 (mRNA)
NP_006639 (protein)

XM_127323 (mRNA)
XP_127323 (protein)

Location

Chr 9: 94.99 - 95.12 Mb

Chr 13: 49.05 - 49.16 Mb

Pubmed search

[1]

[2]

WNK lysine deficient protein kinase 2, also known as WNK2, is a human gene.^[1]

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine.^[1]

[edit] References

^ ^a ^b Entrez Gene: WNK2 WNK lysine deficient protein kinase 2.

[edit] Further reading

Scanlan MJ, Chen YT, Williamson B, et al. (1998). "Characterization of human colon cancer antigens recognized by autologous antibodies.". Int. J. Cancer 76 (5): 652-8. PMID 9610721.
Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (6): 347-55. PMID 11214970.
Ito M, Shichijo S, Tsuda N, et al. (2001). "Molecular basis of T cell-mediated recognition of pancreatic cancer cells.". Cancer Res. 61 (5): 2038-46. PMID 11280764.
Wilson FH, Disse-Nicodème S, Choate KA, et al. (2001). "Human hypertension caused by mutations in WNK kinases.". Science 293 (5532): 1107-12. doi:10.1126/science.1062844. PMID 11498583.
Veríssimo F, Jordan P (2001). "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.". Oncogene 20 (39): 5562-9. doi:10.1038/sj.onc.1204726. PMID 11571656.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Moniz S, Veríssimo F, Matos P, et al. (2007). "Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2.". Oncogene 26 (41): 6071-81. doi:10.1038/sj.onc.1210706. PMID 17667937.