WNK1

From Wikipedia, the free encyclopedia

WNK lysine deficient protein kinase 1

PDB rendering based on 1t4h.

Available structures: 1t4h

Identifiers

Symbol(s)

WNK1; KDP; KIAA0344; PHA2C; PRKWNK1

External IDs

OMIM: 605232 MGI: 2442092 HomoloGene: 14253

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein kinase inhibitor activity • protein binding • ATP binding • transferase activity
Cellular Component:	• soluble fraction • cytoplasm • vesicular fraction
Biological Process:	• protein amino acid phosphorylation • ion transport • protein kinase cascade • regulation of cellular process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018979 (mRNA)
NP_061852 (protein)

XM_001004362 (mRNA)
XP_001004362 (protein)

Location

Chr 12: 0.73 - 0.89 Mb

Chr 6: 119.89 - 120 Mb

Pubmed search

[1]

[2]

WNK lysine deficient protein kinase 1, also known as WNK1, is a human gene.^[1]

The WNK1 gene encodes a cytoplasmic serine-threonine kinase expressed in distal nephron.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: WNK1 WNK lysine deficient protein kinase 1.

[edit] Further reading

Hart GW, Haltiwanger RS, Holt GD, Kelly WG (1989). "Nucleoplasmic and cytoplasmic glycoproteins.". Ciba Found. Symp. 145: 102–12, discussion 112–8. PMID 2507249.
Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Xu BE, Lee BH, Min X, et al. (2005). "WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension.". Cell Res. 15 (1): 6–10. doi:10.1038/sj.cr.7290256. PMID 15686619.
Subramanya AR, Yang CL, McCormick JA, Ellison DH (2006). "WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron.". Kidney Int. 70 (4): 630–4. doi:10.1038/sj.ki.5001634. PMID 16820787.
Huang CL, Kuo E (2007). "Mechanisms of disease: WNK-ing at the mechanism of salt-sensitive hypertension.". Nature clinical practice. Nephrology 3 (11): 623–30. doi:10.1038/ncpneph0638. PMID 17957199.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. PMID 9205841.
Moore TM, Garg R, Johnson C, et al. (2000). "PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization.". J. Biol. Chem. 275 (6): 4311–22. PMID 10660600.
Disse-Nicodème S, Achard JM, Desitter I, et al. (2000). "A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension.". Am. J. Hum. Genet. 67 (2): 302–10. PMID 10869238.
Wilson FH, Disse-Nicodème S, Choate KA, et al. (2001). "Human hypertension caused by mutations in WNK kinases.". Science 293 (5532): 1107–12. doi:10.1126/science.1062844. PMID 11498583.
Veríssimo F, Jordan P (2001). "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.". Oncogene 20 (39): 5562–9. doi:10.1038/sj.onc.1204726. PMID 11571656.
Xu BE, Min X, Stippec S, et al. (2003). "Regulation of WNK1 by an autoinhibitory domain and autophosphorylation.". J. Biol. Chem. 277 (50): 48456–62. doi:10.1074/jbc.M207917200. PMID 12374799.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Vitari AC, Deak M, Collins BJ, et al. (2004). "WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate.". Biochem. J. 378 (Pt 1): 257–68. doi:10.1042/BJ20031692. PMID 14611643.
Delaloy C, Lu J, Houot AM, et al. (2004). "Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform.". Mol. Cell. Biol. 23 (24): 9208–21. PMID 14645531.
Xu BE, Stippec S, Lenertz L, et al. (2004). "WNK1 activates ERK5 by an MEKK2/3-dependent mechanism.". J. Biol. Chem. 279 (9): 7826–31. doi:10.1074/jbc.M313465200. PMID 14681216.
Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.". Genomics 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.