WIPF2

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WAS/WASL interacting protein family, member 2
Identifiers
Symbol(s) WIPF2; WICH; WIRE
External IDs OMIM: 609692 MGI: 1924462 HomoloGene: 15777
Orthologs
Human Mouse
Entrez 147179 68524
Ensembl ENSG00000171475 ENSMUSG00000038013
Uniprot Q8TF74 Q6PEV3
Refseq NM_133264 (mRNA)
NP_573571 (protein)		 XM_979837 (mRNA)
XP_984931 (protein)
Location Chr 17: 35.63 - 35.69 Mb Chr 11: 98.68 - 98.72 Mb
Pubmed search [1] [2]

WAS/WASL interacting protein family, member 2, also known as WIPF2, is a human gene.[1]

This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery.[1]

[edit] References

  1. ^ a b Entrez Gene: WIPF2 WAS/WASL interacting protein family, member 2.

[edit] Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Kato M, Miki H, Kurita S, et al. (2002). "WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation.". Biochem. Biophys. Res. Commun. 291 (1): 41–7. doi:10.1006/bbrc.2002.6406. PMID 11829459. 
  • Aspenström P (2002). "The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor.". Exp. Cell Res. 279 (1): 21–33. PMID 12213210. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMID 15498874. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
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