William Spencer, 2nd Baron Spencer

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William Spencer, 2nd Baron Spencer of Wormleighton (c. December 1591 - 19 December 1636) was an English peer.

William Spencer was born to Robert Spencer, 1st Baron Spencer and his wife, Margaret Willoughby, and was baptised on 4 January 1591 at Brington, Northamptonshire. He attended Magdalen College, Oxford and became a Member of Parliament for Brackley in 1614, for Northamptonshire (1620-22 & 1624-27). From 6 May 1618 to 1621, Spencer held the office of Deputy Lieutenant of Northamptonshire. On 25 October 1627, he succeeded to the title of 2nd Baron Spencer, of Wormleighton.

In 1615, William Spencer married Lady Penelope Wriothesley, daughter of Henry Wriothesley, 3rd Earl of Southampton. Their eldest son was Henry Spencer, 1st Earl of Sunderland.

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