Talk:Wilson's Heart

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[edit] Various medical info

Just a few points; I might make these edits later:

- It's Huntington's Chorea, not "Cholera." - If I understood correctly, Amber couldn't filter the pills b/c of the kidney damage in the accident, not because it was a particularly high dosage. I might be wrong, though.

Scot0127 (talk) 03:40, 20 May 2008 (UTC)

No, you're correct. The drug she was on was Amantadine, which is an antiviral (with antiparkinsonic properties to boot) that has some particularly toxic side-effects if mis-used, or in Ambers case, if left in the body instead of being metabolized and filtered out. The reason the dialysis would have been pointless is because, like House stated, it bonds with protein. Kidneys could take care of that, but a dialysis machine can't as it's only a crude filter by comparison, designed as a stop-gap in the case of renal disease or renal failure. She "overdosed" not by taking too many, but by virtue of the drug hanging around and not exiting her system. And with the amount of organ damage she'd sustained as a result of the crash AND as a result of the toxicity of the drug, she wouldn't have been able to get any transplants. 124.148.41.66 (talk) 11:14, 20 May 2008 (UTC)

Amantadine is poorly cleared by dialysis, and there have been deaths reported on the medication. The dose for the flu is 100MG twice a day. The only size pill Amantadine comes in is 100MG, so Amber taking two means that she was overdosing herself on itOutofyourelement (talk) 20:33, 21 May 2008 (UTC)

This is probably nothing, but there is a bit of symmetry with the end of last season, when House turns off the blood filtration machine, the woman's heart is still beating, and here Amber dies. —Preceding unsigned comment added by 71.201.176.194 (talk) 06:18, 20 May 2008 (UTC)

That's not a "blood filtration machine", that's a cardiopulmonary bypass machine. Essentially, her heart is no longer working correctly, so they are pumping the blood through a series of chambers designed to "scrub" the CO2 from her venous blood, oxygenate it, and then shunt it back into her arteries. Quite a nifty machine, but as with all mechanical substitutes for natural organs, woefully inefficient. They use them in things like bypass surgery and transplantation. 124.148.41.66 (talk) 11:36, 20 May 2008 (UTC)

Made a minor edit. The article mentioned they analyzed Amber's "EKG" to determine the disease had spread to her brain. That was incorrect - an EKG/ECG measures electrical activity in the cardiac muscle. The actual (correct) diagnostic readout they analyzed was her EEG which measures electrical activity in the brain. I also added the correct reason House entered a coma - cerebral haemmorhage caused by a widening skull fracture, indirectly caused by a complex partial seizure. I changed the wording of "undergoes a ventricular fibrillation" to "suffers a..." as the original wording made it sound more like a diagnostic procedure than an actual serious medical problem. Someone had also referred to amantadine as a symptomatic relief or palliative treatment, when in reality it's an antiviral drug, designed to help fight the infection itself. Paracetamol/acetaminophen, tea and bedrest would be symptomatic relief. So I amended that as well. 124.148.41.66 (talk) 11:28, 20 May 2008 (UTC)

Ugh. On further inspection there's a heap of grammatical errors, as well as some very awkward wording. I'm not in the mood to go through and edit all the faults out. If someone else can do that, but leave my factual edits intact, that'd be much appreciated. 124.148.41.66 (talk) 11:47, 20 May 2008 (UTC)

I am just wondering why they couldn't give Amber other plasma-binding drugs to compitatively expell the amantadine from its bond to the albumin. This is done in other cases of poisoning as well. The other way would be giving drugs that antagonize the effects of the amantadine until it has been eliminated. --131.220.136.195 (talk) 12:13, 20 May 2008 (UTC)

She was in multiple systems failure by the time they discovered the amantadine. She didn't have any systems running that could have metabolized or eliminated the toxins. Adding more medications to that may have just increased the toxic effect on her system. Plus, it made for a much more dramatic storyline if she died :P 124.148.41.66 (talk) 12:21, 20 May 2008 (UTC)
Well, the second one is the point. But normally it should have been possible to antagonize the toxins. Dialysis wouldn't have worked with the albumin bound drugs, but because of the compitative bonding to the plasma proteins it should have been possible to get the amantadine off the albumin with relatively harmless protein binding drugs, and the filtering it out by dialysis. The same kind of mechanism is used in methanol poisoning: giving a high dose of ethanol prevents the methanol from being processed to toxic formaldehyde by the alcohol dehydroxygenase, so that it will leave the body unmetabolized.
But as you said: the storyline demanded her death. --91.55.62.213 (talk) 21:43, 20 May 2008 (UTC)

[edit] Wilson & House at the end of episode

Just wondering, should the part where Wilson waiting for House to wake up be added into the summary? It seemed like Wilson wanted House to see that he was pissed that his friend lived while Amber died, because he didn't go over to his friend or seem happy that at least his best friend survived. I think it would show that their relationship has been strained, if not, damaged. Sorry if this bit of mine doesn't make sense. Facebookery (talk) 15:18, 20 May 2008 (UTC)

It is relevant, but for different reasons I believe. Despite all the distress cause by the loss of Amber, and despite the fact that (we assume) he partially blames House for her death, Wilson was still concerned for House's well-being. He wanted to see if he was alright, but was unable to express more than the most basic level of concern. Also worthy of consideration is the fact that Wilson may have been slowly coming to terms with the fact that if House died, Wilson would be partially to blame, due to the fact that he "guilted" House into the electro-stimulation. Mrfridays (talk) 16:09, 20 May 2008 (UTC)
The most important fact is, that House was near death twice and survived while Amber died. It would have been a strange season 5 if House died at this point. --91.55.62.213 (talk) 21:45, 20 May 2008 (UTC)
Not only would it be strange, but it is kind of hard to call your show "House" when the main character that the show is named after is dead. Soccernamlak (talk) 23:48, 20 May 2008 (UTC)
I don't think that this would necessarily mean the end of the show. After all, they could do a prequel season. Assimilateur (talk) 11:28, 25 May 2008 (UTC)

[edit] Change

A quick Google search shows that 'change' has also been used as a slogan by Hillary Clinton, John McCain, and other politicians from the Democratic and Republican parties. We should not assume it was a necessarily or only a reference to Barack Obama. The wall of a public lavatory is usually a place for insults, not endorsements.


Change, yes. The exact phrase "Vote for Change" was the name of Obama's voter registration campaign, not to mention that both Olivia Wilder and Kal Penn are active campaigners for Obama. 98.223.170.167 (talk) 05:31, 21 May 2008 (UTC)
"Ready for Change" has been a Hillary slogan since Summer 2007. And why did you insert your comment in the middle of mine?FC (talk) 21:24, 21 May 2008 (UTC)

Change has arguably been the major theme of the show since the third season finale.FC (talk) 04:43, 21 May 2008 (UTC)

All of this is generally moot because it's original research. Source that the sticker was a reference to Obama (or Clinton, or even Ron Paul), or remove it. 171.71.37.203 (talk) 21:41, 21 May 2008 (UTC)
Pretty sure I edited the article to reflect both the possibility of it being an endorsement and it being an insult, so readers could draw their own conclusions. You nerds changed it, and even though "Change" is most likely a reference, positive or negative, to Barack Obama's campaign, since none of us are David Shore, or whoever wrote this particular episode, it's safe to assume we do not know for sure (Clarification for idiots: sure = 100% proven fact, ie: a source like a props list stating barack obama campaign sticker or etc.) whose campaign it refers to and if it is a negative or positive reference. As such I agree with the comment above mine that without a source to confirm and stop the political pissing contest over who it refers to and the negative or positive reference arguement the paragraph should be removed. 69.254.55.104 (talk) 20:34, 2 June 2008 (UTC)
I agree; while I often enjoy the cultural references, they are usually original research or synthesis and lend themselves to varying interpretations among editors. But you seem to have major problems maintaining civility. There are more important things to get angry about, like people who mistake "loose" for "lose" and people who drive minivans. (But maybe that's just me). --Fletcher (talk) 22:30, 2 June 2008 (UTC)

[edit] Grammar

I'm constantly frustrated by well-meaning editors who, after inserting their bit of information, leave a trail of blatant grammatical errors. To fix these errors, sometimes I may have to remove entire sentences, or risk making the article too fragmented or long-winded - and I just don't have the heart to do that. (I mean, edits are welcomed, but please, match the level of the article - don't jump between first and third person, and don't add in quotations in the plot summary - and by that I don't mean putting phrases like "but they say no, it's too dangerous". It sounds like a third grader wrote that.) Bockbockchicken (talk) 14:08, 27 May 2008 (UTC)