WHSC2

From Wikipedia, the free encyclopedia


Wolf-Hirschhorn syndrome candidate 2
Identifiers
Symbol(s) WHSC2; FLJ10442; FLJ25112; NELF-A; NELFA; P/OKcl.15
External IDs OMIM: 606026 MGI: 1346098 HomoloGene: 68478
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7469 24116
Ensembl ENSG00000185049 ENSMUSG00000029111
Uniprot Q9H3P2 Q3UK41
Refseq NM_005663 (mRNA)
NP_005654 (protein)		 NM_011914 (mRNA)
NP_036044 (protein)
Location Chr 4: 1.95 - 1.98 Mb Chr 5: 34.21 - 34.25 Mb
Pubmed search [1] [2]

Wolf-Hirschhorn syndrome candidate 2, also known as WHSC2, is a human gene.[1]

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.[1] WHSC2 encodes the NELF-A subunit of the NELF complex.[2]

[edit] References

  1. ^ a b Entrez Gene: WHSC2 Wolf-Hirschhorn syndrome candidate 2.
  2. ^ Narita, Takashi; Yamaguchi, Yuki ; Yano, Keiichi; Sugimoto, Seiji; Chanarat, Sittinan; Wada, Tadashi; Kim, Dong-ki; Hasegawa, Jun; Omori, Masashi; Inukai, Naoto; Endoh, Masaki; Yamada, Tomoko; Handa, Hiroshi (2003). "Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex". MOLECULAR AND CELLULAR BIOLOGY 23: 1863–1873. doi:10.1128/MCB.23.6.1863-1873.2003. PMID 12612062. 

[edit] Further reading

  • Gutmajster E, Rokicka A (2003). "[Genetic determination of Wolf-Hirschhorn syndrome ]". Wiad. Lek. 55 (11-12): 706–10. PMID 12715353. 
  • Stevens M, De Clercq E, Balzarini J (2007). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention.". Med Res Rev 26 (5): 595–625. doi:10.1002/med.20081. PMID 16838299. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Wright TJ, Ricke DO, Denison K, et al. (1997). "A transcript map of the newly defined 165 kb Wolf-Hirschhorn syndrome critical region.". Hum. Mol. Genet. 6 (2): 317–24. PMID 9063753. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Yamaguchi Y, Takagi T, Wada T, et al. (1999). "NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.". Cell 97 (1): 41–51. PMID 10199401. 
  • Wright TJ, Costa JL, Naranjo C, et al. (1999). "Comparative analysis of a novel gene from the Wolf-Hirschhorn/Pitt-Rogers-Danks syndrome critical region.". Genomics 59 (2): 203–12. doi:10.1006/geno.1999.5871. PMID 10409432. 
  • Ping YH, Rana TM (2001). "DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation.". J. Biol. Chem. 276 (16): 12951–8. doi:10.1074/jbc.M006130200. PMID 11112772. 
  • Mariotti M, Manganini M, Maier JA (2001). "Modulation of WHSC2 expression in human endothelial cells.". FEBS Lett. 487 (2): 166–70. PMID 11150502. 
  • Ito M, Shichijo S, Tsuda N, et al. (2001). "Molecular basis of T cell-mediated recognition of pancreatic cancer cells.". Cancer Res. 61 (5): 2038–46. PMID 11280764. 
  • Yamaguchi Y, Filipovska J, Yano K, et al. (2001). "Stimulation of RNA polymerase II elongation by hepatitis delta antigen.". Science 293 (5527): 124–7. doi:10.1126/science.1057925. PMID 11387440. 
  • Yamaguchi Y, Inukai N, Narita T, et al. (2002). "Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.". Mol. Cell. Biol. 22 (9): 2918–27. PMID 11940650. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Zollino M, Lecce R, Fischetto R, et al. (2003). "Mapping the Wolf-Hirschhorn syndrome phenotype outside the currently accepted WHS critical region and defining a new critical region, WHSCR-2.". Am. J. Hum. Genet. 72 (3): 590–7. PMID 12563561. 
  • Narita T, Yamaguchi Y, Yano K, et al. (2003). "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.". Mol. Cell. Biol. 23 (6): 1863–73. PMID 12612062. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
 This article on a gene on chromosome 4 is a stub. You can help Wikipedia by expanding it.