WHSC1L1

From Wikipedia, the free encyclopedia

Wolf-Hirschhorn syndrome candidate 1-like 1

PDB rendering based on 2daq.

Available structures: 2daq

Identifiers

Symbol(s)

WHSC1L1; DKFZp667H044; FLJ20353; MGC126766; MGC142029; NSD3; pp14328

External IDs

OMIM: 607083 MGI: 2142581 HomoloGene: 56960

Gene ontology
Molecular Function:	• protein binding • methyltransferase activity • zinc ion binding • transferase activity • histone-lysine N-methyltransferase activity • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • cell growth • chromatin modification • histone methylation • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_017778 (mRNA)
NP_060248 (protein)

XM_620640 (mRNA)
XP_620640 (protein)

Location

Chr 8: 38.25 - 38.36 Mb

Chr 8: 27.07 - 27.18 Mb

Pubmed search

[1]

[2]

Wolf-Hirschhorn syndrome candidate 1-like 1, also known as WHSC1L1, is a human gene.^[1]

This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1.

[edit] Further reading

Stec I, Nagl SB, van Ommen GJ, den Dunnen JT (2000). "The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?". FEBS Lett. 473 (1): 1–5. PMID 10802047.
Angrand PO, Apiou F, Stewart AF, et al. (2001). "NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines.". Genomics 74 (1): 79–88. doi:10.1006/geno.2001.6524. PMID 11374904.
Stec I, van Ommen GJ, den Dunnen JT (2001). "WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3.". Genomics 76 (1-3): 5–8. doi:10.1006/geno.2001.6581. PMID 11549311.
Rosati R, La Starza R, Veronese A, et al. (2002). "NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15).". Blood 99 (10): 3857–60. PMID 11986249.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Tonon G, Wong KK, Maulik G, et al. (2005). "High-resolution genomic profiles of human lung cancer.". Proc. Natl. Acad. Sci. U.S.A. 102 (27): 9625–30. doi:10.1073/pnas.0504126102. PMID 15983384.
Kim SM, Kee HJ, Eom GH, et al. (2006). "Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity.". Biochem. Biophys. Res. Commun. 345 (1): 318–23. doi:10.1016/j.bbrc.2006.04.095. PMID 16682010.