WFIKKN1

From Wikipedia, the free encyclopedia


WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
PDB rendering based on 2ddi.
Available structures: 2ddi, 2ddj
Identifiers
Symbol(s) WFIKKN1; MGC126651; MGC126655; RJD2; WFIKKN
External IDs OMIM: 608021 MGI: 2670967 HomoloGene: 14244
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 117166 215001
Ensembl ENSG00000127578 ENSMUSG00000071192
Refseq NM_053284 (mRNA)
NP_444514 (protein)		 XM_128578 (mRNA)
XP_128578 (protein)
Location Chr 16: 0.62 - 0.62 Mb Chr 17: 25.61 - 25.61 Mb
Pubmed search [1] [2]

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1, also known as WFIKKN1, is a human gene.[1]

This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases.[1]

[edit] References

  1. ^ a b Entrez Gene: WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1.

[edit] Further reading

  • Liepinsh E, Nagy A, Trexler M, et al. (2006). "Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein.". J. Biomol. NMR 35 (1): 73-8. doi:10.1007/s10858-006-9013-1. PMID 16791741. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197. 
  • Nagy A, Trexler M, Patthy L (2003). "Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein.". Eur. J. Biochem. 270 (9): 2101-7. PMID 12709070. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Trexler M, Bányai L, Patthy L (2003). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules.". Biol. Chem. 383 (1): 223-8. PMID 11928817. 
  • Trexler M, Bányai L, Patthy L (2001). "A human protein containing multiple types of protease-inhibitory modules.". Proc. Natl. Acad. Sci. U.S.A. 98 (7): 3705-9. doi:10.1073/pnas.061028398. PMID 11274388. 
  • Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339-52. PMID 11157797. 
 This article on a gene on chromosome 16 is a stub. You can help Wikipedia by expanding it.