WFDC5

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WAP four-disulfide core domain 5
Identifiers
Symbol(s) WFDC5; PRG5; WAP1; dJ211D12.5
External IDs OMIM: 605161 MGI: 2384800 HomoloGene: 17072
Orthologs
Human Mouse
Entrez 149708 209232
Ensembl ENSG00000175121 ENSMUSG00000040154
Uniprot Q8TCV5 n/a
Refseq NM_145652 (mRNA)
NP_663627 (protein)		 NM_145369 (mRNA)
NP_663344 (protein)
Location Chr 20: 43.17 - 43.18 Mb Chr 2: 163.87 - 163.87 Mb
Pubmed search [1] [2]

WAP four-disulfide core domain 5, also known as WFDC5, is a human gene.[1]

This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.[1]

[edit] References

  1. ^ a b Entrez Gene: WFDC5 WAP four-disulfide core domain 5.

[edit] Further reading

  • Horikoshi N, Cong J, Kley N, Shenk T (1999). "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene.". Biochem. Biophys. Res. Commun. 261 (3): 864–9. doi:10.1006/bbrc.1999.1123. PMID 10441517. 
  • Ranganathan S, Simpson KJ, Shaw DC, Nicholas KR (2000). "The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling.". J. Mol. Graph. Model. 17 (2): 106–13, 134–6. PMID 10680116. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
  • Clauss A, Lilja H, Lundwall A (2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein.". Biochem. J. 368 (Pt 1): 233–42. doi:10.1042/BJ20020869. PMID 12206714. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Nukumi N, Seki M, Iwamori T, et al. (2006). "Analysis of the promoter of mutated human whey acidic protein (WAP) gene.". J. Reprod. Dev. 52 (2): 315–20. PMID 16462094. 
  • Mukhopadhyay SS, Rosen JM (2007). "The C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells.". Biochem. Biophys. Res. Commun. 358 (3): 770–6. doi:10.1016/j.bbrc.2007.04.185. PMID 17511965. 
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