WDR8

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WD repeat domain 8
Identifiers
Symbol(s) WDR8; FLJ20430; MGC99569
External IDs OMIM: 606040 MGI: 1891749 HomoloGene: 9857
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 49856 59002
Ensembl ENSG00000116213 ENSMUSG00000029029
Uniprot Q9P2S5 Q3T993
Refseq NM_017818 (mRNA)
NP_060288 (protein)		 NM_021499 (mRNA)
NP_067474 (protein)
Location Chr 1: 3.54 - 3.56 Mb Chr 4: 152.99 - 153 Mb
Pubmed search [1] [2]

WD repeat domain 8, also known as WDR8, is a human gene.[1]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This family member is 89% identical to the mouse Wdr8 protein at the amino acid level. The function of this protein is not known, and the mouse studies suggest that the Wdr8 protein may play a role in the process of ossification.[1]

[edit] References

  1. ^ a b Entrez Gene: WDR8 WD repeat domain 8.

[edit] Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Koshizuka Y, Ikegawa S, Sano M, et al. (2001). "Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family.". Genomics 72 (3): 252–9. doi:10.1006/geno.2000.6475. PMID 11401440. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
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