WDR57

From Wikipedia, the free encyclopedia

WD repeat domain 57 (U5 snRNP specific)

Identifiers

WDR57; 40K; FLJ41108; MGC1910; PRP8BP; PRPF8BP; RP11-490K7.3; SPF38

External IDs

Gene ontology
Molecular Function:	• protein binding • RNA splicing factor activity, transesterification mechanism
Cellular Component:	• nucleus • spliceosome • snRNP U5 • small nucleolar ribonucleoprotein complex
Biological Process:	• mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_004814 (mRNA)
NP_004805 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 1: 31.51 - 31.54 Mb

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Pubmed search

[1]

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WD repeat domain 57 (U5 snRNP specific), also known as WDR57, is a gene found in many organisms, including, but not limited to Homo sapiens, Gallus gallus, Pan troglodytes, Canus lupus familiaris, Bos taurus, Mus musculus, and Rattus norvegicus.^[1]

This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs.^[1]

[edit] References

^ ^a ^b Entrez Gene: WDR57 WD repeat domain 57 (U5 snRNP specific).

[edit] Further reading

Turner IA, Norman CM, Churcher MJ, Newman AJ (2005). "Roles of the U5 snRNP in spliceosome dynamics and catalysis.". Biochem. Soc. Trans. 32 (Pt 6): 928–31. doi:10.1042/BST0320928. PMID 15506927.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
Achsel T, Ahrens K, Brahms H, et al. (1998). "The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein.". Mol. Cell. Biol. 18 (11): 6756–66. PMID 9774689.
Makarov EM, Makarova OV, Achsel T, Lührmann R (2000). "The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions.". J. Mol. Biol. 298 (4): 567–75. doi:10.1006/jmbi.2000.3685. PMID 10788320.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426–39. PMID 11991638.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Jordanova A, Irobi J, Thomas FP, et al. (2006). "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy.". Nat. Genet. 38 (2): 197–202. doi:10.1038/ng1727. PMID 16429158.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Liu S, Rauhut R, Vornlocher HP, Lührmann R (2006). "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.". RNA 12 (7): 1418–30. doi:10.1261/rna.55406. PMID 16723661.
Higa LA, Wu M, Ye T, et al. (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.". Nat. Cell Biol. 8 (11): 1277–83. doi:10.1038/ncb1490. PMID 17041588.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.