WBP4
From Wikipedia, the free encyclopedia
WW domain binding protein 4 (formin binding protein 21)
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PDB rendering based on 2dk1. | ||||||||||||||
Available structures: 2dk1 | ||||||||||||||
Identifiers | ||||||||||||||
Symbol(s) | WBP4; FBP21; MGC117310 | |||||||||||||
External IDs | OMIM: 604981 MGI: 109568 HomoloGene: 38287 | |||||||||||||
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RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 11193 | 22380 | ||||||||||||
Ensembl | ENSG00000120688 | ENSMUSG00000022023 | ||||||||||||
Uniprot | O75554 | Q3TUU8 | ||||||||||||
Refseq | NM_007187 (mRNA) NP_009118 (protein) |
NM_018765 (mRNA) NP_061235 (protein) |
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Location | Chr 13: 40.53 - 40.56 Mb | Chr 14: 78.2 - 78.22 Mb | ||||||||||||
Pubmed search | [1] | [2] |
WW domain binding protein 4 (formin binding protein 21), also known as WBP4, is a human gene.[1]
This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A.[1]
[edit] References
[edit] Further reading
- Takahara T, Tasic B, Maniatis T, et al. (2005). "Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site.". Mol. Cell 18 (2): 245–51. doi: . PMID 15837427.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi: . PMID 15489334.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi: . PMID 15057823.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi: . PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: . PMID 12477932.
- Bedford MT, Frankel A, Yaffe MB, et al. (2000). "Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains.". J. Biol. Chem. 275 (21): 16030–6. doi: . PMID 10748127.
- Bedford MT, Reed R, Leder P (1998). "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif.". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10602–7. PMID 9724750.
- Chan DC, Bedford MT, Leder P (1996). "Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.". EMBO J. 15 (5): 1045–54. PMID 8605874.