WBP4

From Wikipedia, the free encyclopedia

WW domain binding protein 4 (formin binding protein 21)

PDB rendering based on 2dk1.

Available structures: 2dk1

Identifiers

Symbol(s)

WBP4; FBP21; MGC117310

External IDs

OMIM: 604981 MGI: 109568 HomoloGene: 38287

Gene ontology
Molecular Function:	• nucleic acid binding • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus • spliceosome
Biological Process:	• mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007187 (mRNA)
NP_009118 (protein)

NM_018765 (mRNA)
NP_061235 (protein)

Location

Chr 13: 40.53 - 40.56 Mb

Chr 14: 78.2 - 78.22 Mb

Pubmed search

[1]

[2]

WW domain binding protein 4 (formin binding protein 21), also known as WBP4, is a human gene.^[1]

This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A.^[1]

[edit] References

^ ^a ^b Entrez Gene: WBP4 WW domain binding protein 4 (formin binding protein 21).

[edit] Further reading

Takahara T, Tasic B, Maniatis T, et al. (2005). "Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site.". Mol. Cell 18 (2): 245–51. doi:10.1016/j.molcel.2005.03.018. PMID 15837427.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bedford MT, Frankel A, Yaffe MB, et al. (2000). "Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains.". J. Biol. Chem. 275 (21): 16030–6. doi:10.1074/jbc.M909368199. PMID 10748127.
Bedford MT, Reed R, Leder P (1998). "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif.". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10602–7. PMID 9724750.
Chan DC, Bedford MT, Leder P (1996). "Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.". EMBO J. 15 (5): 1045–54. PMID 8605874.