WBP2

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WW domain binding protein 2
Identifiers
Symbol(s) WBP2; MGC18269; WBP-2
External IDs OMIM: 606962 MGI: 104709 HomoloGene: 32160
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23558 22378
Ensembl ENSG00000132471 ENSMUSG00000034341
Uniprot Q969T9 Q3TRG5
Refseq NM_012478 (mRNA)
NP_036610 (protein)		 NM_016852 (mRNA)
NP_058548 (protein)
Location Chr 17: 71.35 - 71.36 Mb Chr 11: 115.89 - 115.9 Mb
Pubmed search [1] [2]

WW domain binding protein 2, also known as WBP2, is a human gene.[1]

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined.[1]

[edit] References

  1. ^ a b Entrez Gene: WBP2 WW domain binding protein 2.

[edit] Further reading

  • Chen HI, Sudol M (1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7819-23. PMID 7644498. 
  • Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets.". J. Biol. Chem. 272 (23): 14611-6. PMID 9169421. 
  • Chen HI, Einbond A, Kwak SJ, et al. (1997). "Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands.". J. Biol. Chem. 272 (27): 17070-7. PMID 9202023. 
  • Jolliffe CN, Harvey KF, Haines BP, et al. (2001). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4.". Biochem. J. 351 Pt 3: 557-65. PMID 11042109. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nitsch R, Di Palma T, Mascia A, Zannini M (2004). "WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8.". Biochem. J. 377 (Pt 3): 553-60. doi:10.1042/BJ20031233. PMID 14531730. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.". Nat. Methods 2 (8): 591-8. doi:10.1038/nmeth776. PMID 16094384. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Dhananjayan SC, Ramamoorthy S, Khan OY, et al. (2006). "WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors.". Mol. Endocrinol. 20 (10): 2343-54. doi:10.1210/me.2005-0533. PMID 16772533. 
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