WBP1

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WW domain binding protein 1
Identifiers
Symbol(s) WBP1; MGC15305; WBP-1
External IDs OMIM: 606961 MGI: 104710 HomoloGene: 8267
Orthologs
Human Mouse
Entrez 23559 22377
Ensembl ENSG00000173027 ENSMUSG00000030035
Uniprot Q96G27 Q8C5Y4
Refseq NM_012477 (mRNA)
NP_036609 (protein)		 NM_016757 (mRNA)
NP_058037 (protein)
Location Chr 2: 74.54 - 74.54 Mb Chr 6: 83.08 - 83.09 Mb
Pubmed search [1] [2]

WW domain binding protein 1, also known as WBP1, is a human gene.[1]

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by a conserved region: XPPXY motif. The function of this protein has not been determined.[1]

[edit] References

  1. ^ a b Entrez Gene: WBP1 WW domain binding protein 1.

[edit] Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ludes-Meyers JH, Kil H, Bednarek AK, et al. (2004). "WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins.". Oncogene 23 (29): 5049–55. doi:10.1038/sj.onc.1207680. PMID 15064722. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Jolliffe CN, Harvey KF, Haines BP, et al. (2001). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4.". Biochem. J. 351 Pt 3: 557–65. PMID 11042109. 
  • Chen HI, Einbond A, Kwak SJ, et al. (1997). "Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands.". J. Biol. Chem. 272 (27): 17070–7. PMID 9202023. 
  • Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets.". J. Biol. Chem. 272 (23): 14611–6. PMID 9169421. 
  • Chen HI, Sudol M (1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7819–23. PMID 7644498. 
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