WBP11

From Wikipedia, the free encyclopedia

WW domain binding protein 11

Identifiers

WBP11; DKFZp779M1063; NPWBP; SIPP1

External IDs

Gene ontology
Molecular Function:	• single-stranded DNA binding • protein binding
Cellular Component:	• nucleus
Biological Process:	• rRNA processing • mRNA processing • RNA splicing

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_016312 (mRNA)
NP_057396 (protein)

NM_021714 (mRNA)
NP_068360 (protein)

Location

n/a

Chr 6: 136.78 - 136.79 Mb

Pubmed search

[1]

[2]

WW domain binding protein 11, also known as WBP11, is a human gene.^[1]

This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus.^[1]

[edit] References

^ ^a ^b Entrez Gene: WBP11 WW domain binding protein 11.

[edit] Further reading

Komuro A, Saeki M, Kato S (2000). "Association of two nuclear proteins, Npw38 and NpwBP, via the interaction between the WW domain and a novel proline-rich motif containing glycine and arginine.". J. Biol. Chem. 274 (51): 36513–9. PMID 10593949.
Bedford MT, Sarbassova D, Xu J, et al. (2000). "A novel pro-Arg motif recognized by WW domains.". J. Biol. Chem. 275 (14): 10359–69. PMID 10744724.
Craggs G, Finan PM, Lawson D, et al. (2001). "A nuclear SH3 domain-binding protein that colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks.". J. Biol. Chem. 276 (32): 30552–60. doi:10.1074/jbc.M103142200. PMID 11375989.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Llorian M, Beullens M, Andrés I, et al. (2004). "SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1.". Biochem. J. 378 (Pt 1): 229–38. doi:10.1042/BJ20030950. PMID 14640981.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Llorian M, Beullens M, Lesage B, et al. (2006). "Nucleocytoplasmic shuttling of the splicing factor SIPP1.". J. Biol. Chem. 280 (46): 38862–9. doi:10.1074/jbc.M509185200. PMID 16162498.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.