WARS2

From Wikipedia, the free encyclopedia

Tryptophanyl tRNA synthetase 2, mitochondrial

Identifiers

External IDs

OMIM: 604733 MGI: 1917810 HomoloGene: 5673

Gene ontology
Molecular Function:	• nucleotide binding • tryptophan-tRNA ligase activity • ATP binding • ligase activity
Cellular Component:	• soluble fraction • mitochondrion
Biological Process:	• vasculogenesis • tryptophanyl-tRNA aminoacylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015836 (mRNA)
NP_056651 (protein)

NM_027462 (mRNA)
NP_081738 (protein)

Location

Chr 1: 119.38 - 119.48 Mb

Chr 3: 99.27 - 99.35 Mb

Pubmed search

[1]

[2]

Tryptophanyl tRNA synthetase 2, mitochondrial, also known as WARS2, is a human gene.^[1]

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: WARS2 tryptophanyl tRNA synthetase 2, mitochondrial.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Martinez-Dominguez MT, Justesen J, Kruse TA, Hansen LL (1999). "Assignment of the human mitochondrial tryptophanyl-tRNA synthetase (WARS2) to 1p13.3-->p13.1 by radiation hybrid mapping.". Cytogenet. Cell Genet. 83 (3-4): 249–50. PMID 10072595.
Jorgensen R, Søgaard TM, Rossing AB, et al. (2000). "Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase.". J. Biol. Chem. 275 (22): 16820–6. PMID 10828066.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Liu J, Shue E, Ewalt KL, Schimmel P (2004). "A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase.". Nucleic Acids Res. 32 (2): 719–27. doi:10.1093/nar/gkh240. PMID 14757836.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Guo LT, Chen XL, Zhao BT, et al. (2007). "Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311.". Nucleic Acids Res. 35 (17): 5934–43. doi:10.1093/nar/gkm633. PMID 17726052.