VTCN1

From Wikipedia, the free encyclopedia


V-set domain containing T cell activation inhibitor 1
Identifiers
Symbol(s) VTCN1; B7-H4; B7H4; B7S1; B7X; B7h.5; FLJ22418; PRO1291; RP11-229A19.4; VCTN1
External IDs OMIM: 608162 MGI: 3039619 HomoloGene: 11627
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 79679 242122
Ensembl ENSG00000134258 ENSMUSG00000051076
Refseq NM_024626 (mRNA)
NP_078902 (protein)		 NM_178594 (mRNA)
NP_848709 (protein)
Location Chr 1: 117.49 - 117.56 Mb Chr 3: 100.95 - 101.02 Mb
Pubmed search [1] [2]

V-set domain containing T cell activation inhibitor 1, also known as VTCN1, is a human gene.[1]

B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: VTCN1 V-set domain containing T cell activation inhibitor 1.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Watanabe N, Gavrieli M, Sedy JR, et al. (2003). "BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.". Nat. Immunol. 4 (7): 670–9. doi:10.1038/ni944. PMID 12796776. 
  • Sica GL, Choi IH, Zhu G, et al. (2003). "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.". Immunity 18 (6): 849–61. PMID 12818165. 
  • Prasad DV, Richards S, Mai XM, Dong C (2003). "B7S1, a novel B7 family member that negatively regulates T cell activation.". Immunity 18 (6): 863–73. PMID 12818166. 
  • Zang X, Loke P, Kim J, et al. (2003). "B7x: a widely expressed B7 family member that inhibits T cell activation.". Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10388–92. doi:10.1073/pnas.1434299100. PMID 12920180. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Choi IH, Zhu G, Sica GL, et al. (2004). "Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family.". J. Immunol. 171 (9): 4650–4. PMID 14568939. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
  • Salceda S, Tang T, Kmet M, et al. (2005). "The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation.". Exp. Cell Res. 306 (1): 128–41. doi:10.1016/j.yexcr.2005.01.018. PMID 15878339. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Kryczek I, Zou L, Rodriguez P, et al. (2006). "B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma.". J. Exp. Med. 203 (4): 871–81. doi:10.1084/jem.20050930. PMID 16606666. 
  • Kryczek I, Wei S, Zou L, et al. (2006). "Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells.". J. Immunol. 177 (1): 40–4. PMID 16785496. 
  • Krambeck AE, Thompson RH, Dong H, et al. (2006). "B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival.". Proc. Natl. Acad. Sci. U.S.A. 103 (27): 10391–6. doi:10.1073/pnas.0600937103. PMID 16798883. 
  • Chen Y, Yang C, Xie Z, et al. (2007). "Expression of the novel co-stimulatory molecule B7-H4 by renal tubular epithelial cells.". Kidney Int. 70 (12): 2092–9. doi:10.1038/sj.ki.5001867. PMID 17051145. 
  • Simon I, Katsaros D, Rigault de la Longrais I, et al. (2007). "B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression.". Gynecol. Oncol. 106 (2): 334–41. doi:10.1016/j.ygyno.2007.03.035. PMID 17498784. 
  • Miyatake T, Tringler B, Liu W, et al. (2007). "B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration.". Gynecol. Oncol. 106 (1): 119–27. doi:10.1016/j.ygyno.2007.03.039. PMID 17509674. 
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