VSX2

From Wikipedia, the free encyclopedia

Ceh-10 homeodomain containing homolog (C. elegans)

Identifiers

CHX10; HOX10; MCOP2; MCOPCB3; RET1

External IDs

OMIM: 142993 MGI: 88401 HomoloGene: 7266

Gene ontology
Molecular Function:	• transcription factor activity • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • multicellular organismal development • visual perception • negative regulation of cell proliferation • cell fate commitment • response to stimulus

Orthologs

Human

Mouse

Refseq

NM_182894 (mRNA)
NP_878314 (protein)

NM_007701 (mRNA)
NP_031727 (protein)

Location

Chr 14: 73.78 - 73.8 Mb

Chr 12: 85.46 - 85.49 Mb

Pubmed search

[1]

[2]

Ceh-10 homeodomain containing homolog (C. elegans), also known as CHX10, is a human gene.^[1]

[edit] References

^ Entrez Gene: CHX10 ceh-10 homeodomain containing homolog (C. elegans).

[edit] Further reading

McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes.". Genomics 7 (3): 460. PMID 1973146.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074.
Ferda Percin E, Ploder LA, Yu JJ, et al. (2000). "Human microphthalmia associated with mutations in the retinal homeobox gene CHX10.". Nat. Genet. 25 (4): 397–401. doi:10.1038/78071. PMID 10932181.
Mikkola I, Bruun JA, Holm T, Johansen T (2001). "Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins.". J. Biol. Chem. 276 (6): 4109–18. doi:10.1074/jbc.M008882200. PMID 11069920.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
Bar-Yosef U, Abuelaish I, Harel T, et al. (2005). "CHX10 mutations cause non-syndromic microphthalmia/ anophthalmia in Arab and Jewish kindreds.". Hum. Genet. 115 (4): 302–9. doi:10.1007/s00439-004-1154-2. PMID 15257456.
Dorval KM, Bobechko BP, Ahmad KF, Bremner R (2005). "Transcriptional activity of the paired-like homeodomain proteins CHX10 and VSX1.". J. Biol. Chem. 280 (11): 10100–8. doi:10.1074/jbc.M412676200. PMID 15647262.
Kuiper H, Spötter A, Williams JL, et al. (2005). "Physical mapping of CHX10, ALDH6A1, and ABCD4 on bovine chromosome 10q34.". Cytogenet. Genome Res. 109 (4): 533. PMID 15909363.
Dorval KM, Bobechko BP, Fujieda H, et al. (2006). "CHX10 targets a subset of photoreceptor genes.". J. Biol. Chem. 281 (2): 744–51. doi:10.1074/jbc.M509470200. PMID 16236706.
Faiyaz-Ul-Haque M, Zaidi SH, Al-Mureikhi MS, et al. (2007). "Mutations in the CHX10 gene in non-syndromic microphthalmia/anophthalmia patients from Qatar.". Clin. Genet. 72 (2): 164–6. doi:10.1111/j.1399-0004.2007.00846.x. PMID 17661825.