VPS4B

From Wikipedia, the free encyclopedia

Vacuolar protein sorting 4 homolog B (S. cerevisiae)

PDB rendering based on 1wr0.

Available structures: 1wr0, 1xwi, 2cpt

Identifiers

Symbol(s)

VPS4B; MIG1; SKD1; VPS4-2

External IDs

OMIM: 609983 MGI: 1100499 HomoloGene: 37976

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • ATP binding • ATPase activity, coupled
Cellular Component:	• endosome • vacuole • membrane
Biological Process:	• regulation of transcription, DNA-dependent • membrane fusion • peroxisome organization and biogenesis • endosome transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004869 (mRNA)
NP_004860 (protein)

NM_009190 (mRNA)
NP_033216 (protein)

Location

Chr 18: 59.21 - 59.24 Mb

Chr 1: 108.6 - 108.62 Mb

Pubmed search

[1]

[2]

Vacuolar protein sorting 4 homolog B (S. cerevisiae), also known as VPS4B, is a human gene.^[1]

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.^[1]

[edit] References

^ ^a ^b Entrez Gene: VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae).

[edit] Further reading

Périer F, Coulter KL, Liang H, et al. (1994). "Identification of a novel mammalian member of the NSF/CDC48p/Pas1p/TBP-1 family through heterologous expression in yeast.". FEBS Lett. 351 (2): 286–90. PMID 8082782.
Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. PMID 9653160.
Scheuring S, Bodor O, Röhricht RA, et al. (1999). "Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking.". Gene 234 (1): 149–59. PMID 10393249.
Bishop N, Woodman P (2000). "ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking.". Mol. Biol. Cell 11 (1): 227–39. PMID 10637304.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (2002). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins.". J. Cell. Sci. 114 (Pt 13): 2395–404. PMID 11559748.
Scheuring S, Röhricht RA, Schöning-Burkhardt B, et al. (2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking.". J. Mol. Biol. 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Beyer A, Scheuring S, Müller S, et al. (2003). "Comparative sequence and expression analyses of four mammalian VPS4 genes.". Gene 305 (1): 47–59. PMID 12594041.
Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding.". Cell 114 (6): 689–99. PMID 14505569.
von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding.". Cell 114 (6): 701–13. PMID 14505570.
Fujita H, Umezuki Y, Imamura K, et al. (2005). "Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B.". J. Cell. Sci. 117 (Pt 14): 2997–3009. doi:10.1242/jcs.01170. PMID 15173323.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Katoh K, Suzuki H, Terasawa Y, et al. (2006). "The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101, and Ca2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B.". Biochem. J. 391 (Pt 3): 677–85. doi:10.1042/BJ20050398. PMID 16004603.
Takasu H, Jee JG, Ohno A, et al. (2005). "Structural characterization of the MIT domain from human Vps4b.". Biochem. Biophys. Res. Commun. 334 (2): 460–5. doi:10.1016/j.bbrc.2005.06.110. PMID 16018968.
Scott A, Chung HY, Gonciarz-Swiatek M, et al. (2005). "Structural and mechanistic studies of VPS4 proteins.". EMBO J. 24 (20): 3658–69. doi:10.1038/sj.emboj.7600818. PMID 16193069.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Welsch S, Habermann A, Jäger S, et al. (2007). "Ultrastructural analysis of ESCRT proteins suggests a role for endosome-associated tubular-vesicular membranes in ESCRT function.". Traffic 7 (11): 1551–66. doi:10.1111/j.1600-0854.2006.00489.x. PMID 17014699.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Lambert C, Döring T, Prange R (2007). "Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin.". J. Virol. 81 (17): 9050–60. doi:10.1128/JVI.00479-07. PMID 17553870.