VPS39

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Vacuolar protein sorting 39 homolog (S. cerevisiae)
Identifiers
Symbol(s) VPS39; TLP; FLJ21681; FLJ46546; KIAA0770; VAM6; hVam6p
External IDs MGI: 2443189 HomoloGene: 41025
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23339 269338
Ensembl ENSG00000166887 ENSMUSG00000027291
Uniprot Q96JC1 Q3TC98
Refseq NM_015289 (mRNA)
NP_056104 (protein)		 NM_147153 (mRNA)
NP_671495 (protein)
Location Chr 15: 40.24 - 40.29 Mb Chr 2: 120.01 - 120.04 Mb
Pubmed search [1] [2]

Vacuolar protein sorting 39 homolog (S. cerevisiae), also known as VPS39, is a human gene.[1]

This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway.[1]

[edit] References

  1. ^ a b Entrez Gene: VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae).

[edit] Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954. 
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277-86. PMID 9872452. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166. 
  • Caplan S, Hartnell LM, Aguilar RC, et al. (2001). "Human Vam6p promotes lysosome clustering and fusion in vivo.". J. Cell Biol. 154 (1): 109-22. PMID 11448994. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Felici A, Wurthner JU, Parks WT, et al. (2003). "TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling.". EMBO J. 22 (17): 4465-77. doi:10.1093/emboj/cdg428. PMID 12941698. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901. 
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