VPS35

From Wikipedia, the free encyclopedia

Vacuolar protein sorting 35 homolog (S. cerevisiae)

Identifiers

VPS35; DKFZp434E1211; DKFZp434P1672; FLJ10752; FLJ13588; FLJ20388; MEM3

External IDs

OMIM: 606931 MGI: 1890467 HomoloGene: 6221

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• endosome • cytosol • membrane
Biological Process:	• protein transport • retrograde transport, endosome to Golgi

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018206 (mRNA)
NP_060676 (protein)

NM_022997 (mRNA)
NP_075373 (protein)

Location

Chr 16: 45.25 - 45.28 Mb

Chr 8: 88.15 - 88.19 Mb

Pubmed search

[1]

[2]

Vacuolar protein sorting 35 homolog (S. cerevisiae), also known as VPS35, is a human gene.^[1]

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex.^[1]

[edit] References

^ ^a ^b Entrez Gene: VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae).

[edit] Further reading

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Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Edgar AJ, Polak JM (2000). "Human homologues of yeast vacuolar protein sorting 29 and 35.". Biochem. Biophys. Res. Commun. 277 (3): 622-30. doi:10.1006/bbrc.2000.3727. PMID 11062004.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Haft CR, de la Luz Sierra M, Bafford R, et al. (2001). "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes.". Mol. Biol. Cell 11 (12): 4105-16. PMID 11102511.
Zhang P, Yu L, Gao J, et al. (2001). "Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21.". Genomics 70 (2): 253-7. doi:10.1006/geno.2000.6380. PMID 11112353.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
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Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.