VPS33A

From Wikipedia, the free encyclopedia

Vacuolar protein sorting 33 homolog A (S. cerevisiae)

Identifiers

VPS33A; FLJ22395; FLJ23187

External IDs

OMIM: 610034 MGI: 1924823 HomoloGene: 11294

Gene ontology
Cellular Component:	• membrane
Biological Process:	• vesicle docking during exocytosis • protein transport • vesicle-mediated transport • platelet formation • regulation of developmental pigmentation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_022916 (mRNA)
NP_075067 (protein)

NM_029929 (mRNA)
NP_084205 (protein)

Location

Chr 12: 121.28 - 121.32 Mb

Chr 5: 123.79 - 123.83 Mb

Pubmed search

[1]

[2]

Vacuolar protein sorting 33 homolog A (S. cerevisiae), also known as VPS33A, is a human gene.^[1]

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and it encodes a protein similar to the yeast class C Vps33 protein. The mammalian class C VPS proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.^[1]

[edit] References

^ ^a ^b Entrez Gene: VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae).

[edit] Further reading

Pevsner J, Hsu SC, Hyde PS, Scheller RH (1997). "Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking.". Gene 183 (1-2): 7-14. PMID 8996080.
Huizing M, Didier A, Walenta J, et al. (2001). "Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33.". Gene 264 (2): 241-7. PMID 11250079.
Kim BY, Krämer H, Yamamoto A, et al. (2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7.". J. Biol. Chem. 276 (31): 29393-402. doi:10.1074/jbc.M101778200. PMID 11382755.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Suzuki T, Oiso N, Gautam R, et al. (2003). "The mouse organellar biogenesis mutant buff results from a mutation in Vps33a, a homologue of yeast vps33 and Drosophila carnation.". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 1146-50. doi:10.1073/pnas.0237292100. PMID 12538872.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Gissen P, Johnson CA, Gentle D, et al. (2005). "Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights.". Hum. Mol. Genet. 14 (10): 1261-70. doi:10.1093/hmg/ddi137. PMID 15790593.