VPS26A

From Wikipedia, the free encyclopedia

Vacuolar protein sorting 26 homolog A (S. pombe)

PDB rendering based on 2fau.

Available structures: 2fau

Identifiers

Symbol(s)

VPS26A; FLJ12930; HB58; Hbeta58; PEP8A; VPS26

External IDs

OMIM: 605506 MGI: 1353654 HomoloGene: 68420

Gene ontology
Molecular Function:	• protein binding • protein transporter activity
Cellular Component:	• endosome • cytosol • membrane • retromer complex
Biological Process:	• vacuolar transport • protein transport • retrograde transport, endosome to Golgi

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001035260 (mRNA)
NP_001030337 (protein)

NM_133672 (mRNA)
NP_598433 (protein)

Location

Chr 10: 70.55 - 70.6 Mb

Chr 10: 61.85 - 61.88 Mb

Pubmed search

[1]

[2]

Vacuolar protein sorting 26 homolog A (S. pombe), also known as VPS26A, is a human gene.^[1]

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: VPS26A vacuolar protein sorting 26 homolog A (S. pombe).

[edit] Further reading

Lee JJ, Radice G, Perkins CP, Costantini F (1992). "Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion.". Development 115 (1): 277-88. PMID 1638986.
Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175-80. PMID 9653160.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.
Haft CR, de la Luz Sierra M, Bafford R, et al. (2001). "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes.". Mol. Biol. Cell 11 (12): 4105-16. PMID 11102511.
Reddy JV, Seaman MN (2002). "Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval.". Mol. Biol. Cell 12 (10): 3242-56. PMID 11598206.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.
Vergés M, Luton F, Gruber C, et al. (2004). "The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor.". Nat. Cell Biol. 6 (8): 763-9. doi:10.1038/ncb1153. PMID 15247922.
Mingot JM, Bohnsack MT, Jäkle U, Görlich D (2005). "Exportin 7 defines a novel general nuclear export pathway.". EMBO J. 23 (16): 3227-36. doi:10.1038/sj.emboj.7600338. PMID 15282546.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kerr MC, Bennetts JS, Simpson F, et al. (2006). "A novel mammalian retromer component, Vps26B.". Traffic 6 (11): 991-1001. doi:10.1111/j.1600-0854.2005.00328.x. PMID 16190980.
Small SA, Kent K, Pierce A, et al. (2006). "Model-guided microarray implicates the retromer complex in Alzheimer's disease.". Ann. Neurol. 58 (6): 909-19. doi:10.1002/ana.20667. PMID 16315276.
Gullapalli A, Wolfe BL, Griffin CT, et al. (2006). "An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins.". Mol. Biol. Cell 17 (3): 1228-38. doi:10.1091/mbc.E05-09-0899. PMID 16407403.
Shi H, Rojas R, Bonifacino JS, Hurley JH (2006). "The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain.". Nat. Struct. Mol. Biol. 13 (6): 540-8. doi:10.1038/nsmb1103. PMID 16732284.
Riemenschneider M, Schoepfer-Wendels A, Friedrich P, et al. (2007). "No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease.". Neurobiol. Aging 28 (6): 883-4. doi:10.1016/j.neurobiolaging.2006.05.009. PMID 16784798.
Rojas R, Kametaka S, Haft CR, Bonifacino JS (2007). "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.". Mol. Cell. Biol. 27 (3): 1112-24. doi:10.1128/MCB.00156-06. PMID 17101778.