VPS24

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Vacuolar protein sorting 24 homolog (S. cerevisiae)
PDB rendering based on 2gd5.
Available structures: 2gd5
Identifiers
Symbol(s) VPS24; CGI-149; CHMP3; NEDF
External IDs OMIM: 610052 MGI: 1913950 HomoloGene: 6368
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 51652 66700
Ensembl ENSG00000115561 ENSMUSG00000053119
Uniprot Q9Y3E7 Q9CQ10
Refseq NM_001005753 (mRNA)
NP_001005753 (protein)		 XM_973747 (mRNA)
XP_978841 (protein)
Location Chr 2: 86.58 - 86.64 Mb Chr 6: 71.47 - 71.51 Mb
Pubmed search [1] [2]

Vacuolar protein sorting 24 homolog (S. cerevisiae), also known as VPS24, is a human gene.[1]

This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.[1]

[edit] References

  1. ^ a b Entrez Gene: VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae).

[edit] Further reading

  • Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703-13. PMID 10810093. 
  • Wilson EM, Oh Y, Hwa V, Rosenfeld RG (2001). "Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells.". J. Clin. Endocrinol. Metab. 86 (9): 4504-11. PMID 11549700. 
  • Babst M, Katzmann DJ, Estepa-Sabal EJ, et al. (2002). "Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting.". Dev. Cell 3 (2): 271-82. PMID 12194857. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Su ZZ, Kang DC, Chen Y, et al. (2003). "Identification of gene products suppressed by human immunodeficiency virus type 1 infection or gp120 exposure of primary human astrocytes by rapid subtraction hybridization.". J. Neurovirol. 9 (3): 372-89. PMID 12775420. 
  • Whitley P, Reaves BJ, Hashimoto M, et al. (2003). "Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization.". J. Biol. Chem. 278 (40): 38786-95. doi:10.1074/jbc.M306864200. PMID 12878588. 
  • Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding.". Cell 114 (6): 689-99. PMID 14505569. 
  • von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding.". Cell 114 (6): 701-13. PMID 14505570. 
  • Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414-9. doi:10.1073/pnas.2133846100. PMID 14519844. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Lin Y, Kimpler LA, Naismith TV, et al. (2005). "Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1.". J. Biol. Chem. 280 (13): 12799-809. doi:10.1074/jbc.M413968200. PMID 15632132. 
  • Yan Q, Hunt PR, Frelin L, et al. (2005). "mVps24p functions in EGF receptor sorting/trafficking from the early endosome.". Exp. Cell Res. 304 (1): 265-73. doi:10.1016/j.yexcr.2004.11.003. PMID 15707591. 
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Walker GE, Antoniono RJ, Ross HJ, et al. (2006). "Neuroendocrine-like differentiation of non-small cell lung carcinoma cells: regulation by cAMP and the interaction of mac25/IGFBP-rP1 and 25.1.". Oncogene 25 (13): 1943-54. doi:10.1038/sj.onc.1209213. PMID 16302002. 
  • Bache KG, Stuffers S, Malerød L, et al. (2006). "The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.". Mol. Biol. Cell 17 (6): 2513-23. doi:10.1091/mbc.E05-10-0915. PMID 16554368. 
  • Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.". Genomics 88 (3): 333-46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Zamborlini A, Usami Y, Radoshitzky SR, et al. (2007). "Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding.". Proc. Natl. Acad. Sci. U.S.A. 103 (50): 19140-5. doi:10.1073/pnas.0603788103. PMID 17146056. 
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