VPS11

From Wikipedia, the free encyclopedia

Vacuolar protein sorting 11 homolog (S. cerevisiae)

Identifiers

VPS11; END1; PEP5; RNF108; hVPS11

External IDs

OMIM: 608549 MGI: 1918982 HomoloGene: 6673

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • ATP binding • zinc ion binding • metal ion binding
Cellular Component:	• early endosome • actin filament • membrane
Biological Process:	• protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021729 (mRNA)
NP_068375 (protein)

NM_027889 (mRNA)
NP_082165 (protein)

Location

Chr 11: 118.44 - 118.46 Mb

Chr 9: 44.1 - 44.11 Mb

Pubmed search

[1]

[2]

Vacuolar protein sorting 11 homolog (S. cerevisiae), also known as VPS11, is a human gene.^[1]

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.^[1]

[edit] References

^ ^a ^b Entrez Gene: VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Huizing M, Didier A, Walenta J, et al. (2001). "Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33.". Gene 264 (2): 241-7. PMID 11250079.
Kim BY, Krämer H, Yamamoto A, et al. (2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7.". J. Biol. Chem. 276 (31): 29393-402. doi:10.1074/jbc.M101778200. PMID 11382755.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kim BY, Ueda M, Kominami E, et al. (2004). "Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex.". Biochem. Biophys. Res. Commun. 311 (3): 577-82. PMID 14623309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724-9. doi:10.1073/pnas.0404089101. PMID 15498874.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.