VPREB3

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Pre-B lymphocyte gene 3
Identifiers
Symbol(s) VPREB3; 8HS20; N27C7-2
External IDs OMIM: 605017 MGI: 98938 HomoloGene: 7598
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 29802 22364
Ensembl ENSG00000128218 ENSMUSG00000000903
Uniprot Q9UKI3 n/a
Refseq NM_013378 (mRNA)
NP_037510 (protein)		 NM_009514 (mRNA)
NP_033540 (protein)
Location Chr 22: 22.42 - 22.43 Mb Chr 10: 75.39 - 75.39 Mb
Pubmed search [1] [2]

Pre-B lymphocyte gene 3, also known as VPREB3, is a human gene.[1]

The VPREB3 gene product is the human homologue of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-cell differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. The VPREB3 protein associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of VPREB3 is not known, but it may contribute to mu chain transport in pre-B cells.[1]

[edit] References

  1. ^ a b Entrez Gene: VPREB3 pre-B lymphocyte gene 3.

[edit] Further reading

  • Melchers F, Karasuyama H, Haasner D, et al. (1993). "The surrogate light chain in B-cell development.". Immunol. Today 14 (2): 60-8. PMID 8166770. 
  • Ohnishi K, Takemori T (1994). "Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines.". J. Biol. Chem. 269 (45): 28347-53. PMID 7961773. 
  • Rosnet O, Mattéi MG, Delattre O, Schiff C (2000). "VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse.". Cytogenet. Cell Genet. 87 (3-4): 205-8. PMID 10702669. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Rosnet O, Blanco-Betancourt C, Grivel K, et al. (2004). "Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells.". J. Biol. Chem. 279 (11): 10228-36. doi:10.1074/jbc.M312169-A200. PMID 14670953. 
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rangel R, McKeller MR, Sims-Mourtada JC, et al. (2005). "Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript.". J. Biol. Chem. 280 (18): 17807-14. doi:10.1074/jbc.M409479200. PMID 15757909. 
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