Vomilenine reductase

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In enzymology, a vomilenine reductase (EC 1.5.1.32) is an enzyme that catalyzes the chemical reaction

1,2-dihydrovomilenine + NADP⁺ vomilenine + NADPH + H⁺

Thus, the two substrates of this enzyme are 1,2-dihydrovomilenine and NADP⁺, whereas its 3 products are vomilenine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1,2-dihydrovomilenine:NADP+ oxidoreductase. This enzyme participates in indole and ipecac alkaloid biosynthesis.

[edit] References

• IUBMB entry for 1.5.1.32
• BRENDA references for 1.5.1.32 (Recommended.)
• PubMed references for 1.5.1.32
• PubMed Central references for 1.5.1.32
• Google Scholar references for 1.5.1.32
• von Schumann G, Gao S, Stockigt J (2002). "Vomilenine reductase--a novel enzyme catalyzing a crucial step in the biosynthesis of the therapeutically applied antiarrhythmic alkaloid ajmaline". Bioorg. Med. Chem. 10: 1913–8. doi:10.1016/S0968-0896(01)00435-7. PMID 11937349. 

[edit] External links

The CAS registry number for this enzyme class is 462127-03-3.

• IUBMB entry for 1.5.1.32

• KEGG entry for 1.5.1.32

• BRENDA entry for 1.5.1.32

• NiceZyme view of 1.5.1.32

• EC2PDB: PDB structures for 1.5.1.32

• PRIAM entry for 1.5.1.32

• PUMA2 entry for 1.5.1.32

• IntEnz: Integrated Enzyme entry for 1.5.1.32

• MetaCyc entry for 1.5.1.32

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050624: vomilenine reductase

• AMIGO entry for GO code 0050624: vomilenine reductase