Vitamin B12-transporting ATPase

From Wikipedia, the free encyclopedia

In enzymology, a vitamin B12-transporting ATPase (EC 3.6.3.33) is an enzyme that catalyzes the chemical reaction

ATP + H₂O + vitamin B₁2out $\rightleftharpoons$ ADP + phosphate + vitamin B₁2in

The 3 substrates of this enzyme are ATP, H₂O, and vitamin B12, whereas its 3 products are ADP, phosphate, and vitamin B12.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (vitamin B12-importing). This enzyme participates in abc transporters - general.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1L7V and 2QI9.

[edit] References

IUBMB entry for 3.6.3.33
BRENDA references for 3.6.3.33 (Recommended.)
PubMed references for 3.6.3.33
PubMed Central references for 3.6.3.33
Google Scholar references for 3.6.3.33
Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr (1995). "Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases". Res. Microbiol. 146: 271–8. PMID 7569321.
Saier MH Jr (1998). "Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya". Adv. Microb. Physiol. 40: 81–136. PMID 9889977.
Friedrich MJ, de Veaux LC, Kadner RJ (1986). "Nucleotide sequence of the btuCED genes involved in vitamin B12 transport in Escherichia coli and homology with components of periplasmic-binding-protein-dependent transport systems". J. Bacteriol. 167: 928–34. PMID 3528129.