VISA (gene)

From Wikipedia, the free encyclopedia

Virus-induced signaling adapter

Identifiers

VISA; CARDIF; DKFZp666M015; FLJ27482; FLJ41962; IPS-1; KIAA1271; MAVS

External IDs

OMIM: 609676 MGI: 2444773 HomoloGene: 17004

Gene ontology
Molecular Function:	• signal transducer activity • protein binding
Cellular Component:	• mitochondrion • membrane • integral to membrane • outer membrane
Biological Process:	• response to virus • positive regulation of I-kappaB kinase/NF-kappaB cascade • innate immune response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020746 (mRNA)
NP_065797 (protein)

NM_144888 (mRNA)
NP_659137 (protein)

Location

Chr 20: 3.78 - 3.8 Mb

Chr 2: 130.93 - 130.94 Mb

Pubmed search

[1]

[2]

Virus-induced signaling adapter, also known as VISA, is a human gene.^[1]

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: VISA virus-induced signaling adapter.

[edit] Further reading

Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. PMID 10574462.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Seth RB, Sun L, Ea CK, Chen ZJ (2005). "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.". Cell 122 (5): 669–82. doi:10.1016/j.cell.2005.08.012. PMID 16125763.
Kawai T, Takahashi K, Sato S, et al. (2005). "IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.". Nat. Immunol. 6 (10): 981–8. doi:10.1038/ni1243. PMID 16127453.
Xu LG, Wang YY, Han KJ, et al. (2005). "VISA is an adapter protein required for virus-triggered IFN-beta signaling.". Mol. Cell 19 (6): 727–40. doi:10.1016/j.molcel.2005.08.014. PMID 16153868.
Meylan E, Curran J, Hofmann K, et al. (2005). "Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.". Nature 437 (7062): 1167–72. doi:10.1038/nature04193. PMID 16177806.
Li XD, Sun L, Seth RB, et al. (2006). "Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity.". Proc. Natl. Acad. Sci. U.S.A. 102 (49): 17717–22. doi:10.1073/pnas.0508531102. PMID 16301520.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Loo YM, Owen DM, Li K, et al. (2006). "Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection.". Proc. Natl. Acad. Sci. U.S.A. 103 (15): 6001–6. doi:10.1073/pnas.0601523103. PMID 16585524.
Cheng G, Zhong J, Chisari FV (2006). "Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms.". Proc. Natl. Acad. Sci. U.S.A. 103 (22): 8499–504. doi:10.1073/pnas.0602957103. PMID 16707574.
Lin R, Lacoste J, Nakhaei P, et al. (2006). "Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage.". J. Virol. 80 (12): 6072–83. doi:10.1128/JVI.02495-05. PMID 16731946.
Saha SK, Pietras EM, He JQ, et al. (2006). "Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.". EMBO J. 25 (14): 3257–63. doi:10.1038/sj.emboj.7601220. PMID 16858409.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Opitz B, Vinzing M, van Laak V, et al. (2007). "Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication.". J. Biol. Chem. 281 (47): 36173–9. doi:10.1074/jbc.M604638200. PMID 16984921.
Chen Z, Benureau Y, Rijnbrand R, et al. (2007). "GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS.". J. Virol. 81 (2): 964–76. doi:10.1128/JVI.02076-06. PMID 17093192.
Hirata Y, Broquet AH, Menchén L, Kagnoff MF (2007). "Activation of innate immune defense mechanisms by signaling through RIG-I/IPS-1 in intestinal epithelial cells.". J. Immunol. 179 (8): 5425–32. PMID 17911629.