Vinylacetyl-CoA Delta-isomerase

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In enzymology, a vinylacetyl-CoA Delta-isomerase (EC 5.3.3.3) is an enzyme that catalyzes the chemical reaction

vinylacetyl-CoA $\rightleftharpoons$ crotonyl-CoA

Hence, this enzyme has one substrate, vinylacetyl-CoA, and one product, crotonyl-CoA.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is vinylacetyl-CoA Delta3-Delta2-isomerase. Other names in common use include vinylacetyl coenzyme A Delta-isomerase, vinylacetyl coenzyme A isomerase, and Delta3-cis-Delta2-trans-enoyl-CoA isomerase. This enzyme participates in butanoate metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U8V.

[edit] References

IUBMB entry for 5.3.3.3
BRENDA references for 5.3.3.3 (Recommended.)
PubMed references for 5.3.3.3
PubMed Central references for 5.3.3.3
Google Scholar references for 5.3.3.3
Lynen F, Knappe J, Lorch E, Jutting G and Ringelmann E (1959). "Die biochemische Funktion des Biotins". Angew. Chem. 71: 481–486. doi:10.1002/ange.19590711503.
Rilling HC and Coon MJ (1960). "The enzymatic isomerization of alpha-methylvinylacetyl coenzyme A and the specificity of a bacterial alpha-methylcrotonyl coenzyme A carboxylase". J. Biol. Chem. 235: 3087–3092.