Viminol
From Wikipedia, the free encyclopedia
 |
|
|
Viminol
|
|
| Systematic (IUPAC) name | |
| 1-[1-[(2-chlorophenyl)methyl]pyrrol-2-yl]-2-(di(butan-2-yl)amino)ethanol | |
| Identifiers | |
| CAS number | |
| ATC code | N02 |
| PubChem | |
| Chemical data | |
| Formula | C21H31ClN2O |
| Mol. mass | 362.94 g/mol |
| Synonyms | Viminol, Dividol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
Rx-Only |
| Routes | Oral |
Viminol (marketed under the brandname Dividol) is a drug which is an opioid analgesic. It has an unusual chemical structure that is not similar to other opioids.[1][2]
Viminol has both antitussive (cough suppressing) and analgesic (pain reducing) effects. It has six different stereoisomers which have varying properties, with the 2-(R) isomer being a μ-opioid full agonist slightly more potent than morphine, while the 2-(S) isomer is an antagonist.[3] Since vimonol is supplied as a racemic mixture of isomers, the overall effect produces a mixed agonist-antagonist profile similar to that of opioids such as pentazocine, although with somewhat less side effects.[4]
Viminol has similar effects to other opioids, and produces analgesia, sedation and euphoria.
[edit] Side Effects
Side effects are similar to other opiods, and can include:
- Itching
- Nausea
- Sedation
- Respiratory depression - can be potentially life-threatening
However, since viminol is supplied as a racemic mixture of agonist and antagonist isomers, the abuse potential and respiratory depression tends to be less than that of μ-opioid full agonist drugs.
 |
This pharmacology-related article is a stub. You can help Wikipedia by expanding it. |
[edit] References
- ^ Contri AM. Chromatographic separation of diastereoisomers of aminoalcohol salts and their densitometric determination. (Italian). Il Farmaco. 1981 Apr;36(4):215-22.
- ^ Neto JM, Murad JE, Monteiro SS. Psychopharmacological properties of the viminol-p-hydroxybenzoate. Revista Brasileira de Pesquisas Medicas e Biologicas. 1977 Dec;10(6):361-8.
- ^ Shook JE, Kallman MJ, Dewey WL. The discriminative stimulus properties of the R2 isomer of viminol. Pharmacology, Biochemistry and Behaviour. 1984 Jan;20(1):59-62.
- ^ Cinelli M, Costa V, Ventresca GP, Lodola E. Viminol R2 analgesic activity in patients with postoperative pain: comparison with pentazocine. International Journal of Clinical Pharmacology, Therapy and Toxicology. 1986 May;24(5):232-5.
