Vesicle-associated membrane protein 8

From Wikipedia, the free encyclopedia

Vesicle-associated membrane protein 8 (endobrevin)

PDB rendering based on 1gl2.

Available structures: 1gl2

Identifiers

Symbol(s)

VAMP8; EDB; VAMP5

External IDs

OMIM: 603177 MGI: 1336882 HomoloGene: 37846

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• membrane fraction • early endosome • synaptic vesicle • membrane • integral to membrane
Biological Process:	• protein complex assembly • vesicle docking during exocytosis • vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003761 (mRNA)
NP_003752 (protein)

NM_016794 (mRNA)
NP_058074 (protein)

Location

Chr 2: 85.66 - 85.66 Mb

Chr 6: 72.32 - 72.32 Mb

Pubmed search

[1]

[2]

Vesicle-associated membrane protein 8 (endobrevin), also known as VAMP8, is a human gene.^[1]

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. It is associated with the perinuclear vesicular structures of the early endocytic compartment. It has been found that VAMP8 interacts specifically with the soluble NSF-attachment protein (alpha-SNAP), most likely through an VAMP8-containing SNARE complex.^[1]

[edit] References

^ ^a ^b Entrez Gene: VAMP8 vesicle-associated membrane protein 8 (endobrevin).

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Wong SH, Zhang T, Xu Y, et al. (1998). "Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome.". Mol. Biol. Cell 9 (6): 1549–63. PMID 9614193.
Bui TD, Wong SH, Lu L, Hong W (1999). "Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse.". Genomics 54 (3): 579–80. doi:10.1006/geno.1998.5596. PMID 9878266.
Fasshauer D, Antonin W, Margittai M, et al. (1999). "Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties.". J. Biol. Chem. 274 (22): 15440–6. PMID 10336434.
Kim PK, Hollerbach C, Trimble WS, et al. (2000). "Identification of the endoplasmic reticulum targeting signal in vesicle-associated membrane proteins.". J. Biol. Chem. 274 (52): 36876–82. PMID 10601239.
Paumet F, Le Mao J, Martin S, et al. (2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment.". J. Immunol. 164 (11): 5850–7. PMID 10820264.
Antonin W, Holroyd C, Tikkanen R, et al. (2000). "The R-SNARE endobrevin/VAMP-8 mediates homotypic fusion of early endosomes and late endosomes.". Mol. Biol. Cell 11 (10): 3289–98. PMID 11029036.
Antonin W, Holroyd C, Fasshauer D, et al. (2001). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function.". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMID 11101518.
Nagamatsu S, Nakamichi Y, Watanabe T, et al. (2001). "Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules.". J. Cell. Sci. 114 (Pt 1): 219–227. PMID 11112705.
Wade N, Bryant NJ, Connolly LM, et al. (2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells.". J. Biol. Chem. 276 (23): 19820–7. doi:10.1074/jbc.M010838200. PMID 11278762.
Antonin W, Fasshauer D, Becker S, et al. (2002). "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs.". Nat. Struct. Biol. 9 (2): 107–11. doi:10.1038/nsb746. PMID 11786915.
Polgár J, Chung SH, Reed GL (2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion.". Blood 100 (3): 1081–3. PMID 12130530.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Imai A, Nashida T, Yoshie S, Shimomura H (2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane.". Arch. Oral Biol. 48 (8): 597–604. PMID 12828989.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Brinkman JF, Ottenheim CP, de Jong LA, et al. (2006). "VAMP5 and VAMP8 are most likely not involved in primary open-angle glaucoma.". Mol. Vis. 11: 582–6. PMID 16110299.
Oishi Y, Arakawa T, Tanimura A, et al. (2007). "Role of VAMP-2, VAMP-7, and VAMP-8 in constitutive exocytosis from HSY cells.". Histochem. Cell Biol. 125 (3): 273–81. doi:10.1007/s00418-005-0068-y. PMID 16195891.
Shiffman D, Rowland CM, Louie JZ, et al. (2006). "Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction.". Arterioscler. Thromb. Vasc. Biol. 26 (7): 1613–8. doi:10.1161/01.ATV.0000226543.77214.e4. PMID 16690874.