Vesicle-associated membrane protein

From Wikipedia, the free encyclopedia

Vesicle associated membrane protein (VAMP) family of proteins includes proteins with similar structure.

• VAMP1 and VAMP2 proteins known as synaptobrevins are expressed in brain and are constituents of the synaptic vesicles, where they participate in neuromediator release.

• VAMP3 (known as cellubrevin) is ubiquitously expressed and participates in regulated and constitutive exocytosis as a constituent of secretory granules and secretory vesicles.

• VAMP5 and VAMP7 (SYBL1) participate in constitutive exocytosis.
  • VAMP5 is a constituent of secretory vesicles, myotubes and tubulovesicular structures.
  • VAMP7 is found both in secretory granules and endosomes.

• VAMP8 (known as endobrevin) participates in endocytosis and is found in early endosomes. VAMP8 also participates the regulated exocytosis in pancreatic acinar cells.

• VAMP4 is involved in transport from the Golgi.^[1]

[edit] References

1. ^ Steegmaier M, Klumperman J, Foletti DL, Yoo JS, Scheller RH (1999). "Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking". Mol. Biol. Cell 10 (6): 1957–72. PMID 10359608. 

[edit] External links

• MeSH Vesicle-Associated+Membrane+Protein+1

v • d • e Protein: membrane proteins Ankyrin - Arrestin - Calnexin - Connexin - Dystrophin - Ephrin - Heterotrimeric GTP-binding proteins - LDL-receptor-related protein associated protein - Membrane fusion protein (VAMP) - Membrane glycoproteins - Membrane transport proteins - Myelin basic protein - Neurofibromin 2 - Phospholipid transfer proteins - Pore forming toxins - Presenilin - Protoporphyrinogen oxidase - Pulmonary surfactant-associated protein B - Pulmonary surfactant-associated protein C - Spectrin - Tetraspanin - Transmembrane receptors - Utrophin - Vesicular transport proteins