Vertebrate telomerase RNA

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Vertebrate telomerase RNA

Type:	Gene;
2° structure:	Published; PubMed; Machado Lima A
Seed alignment:	Machado Lima A
Avg length:	430.7 nucleotides
Avg identity:	57%

Telomerase is a ribonucleoprotein reverse transcriptase that synthesises telomeric DNA. Telomerase RNAs differ greatly in sequence and structure between vertebrates, ciliates and yeasts, but they share a 5' pseudoknot structure close to the template sequence. Vertebrate telomerase RNAs have a 3' H/ACA snoRNA-like domain. This family also contains viral telomerase RNAs from the Gallid herpes viruses as described by Fragnet et al.^[1]

[edit] References

^ Fragnet, L; Kut E, Rasschaert D (2005). "Comparative functional study of the viral telomerase RNA based on natural mutations". J Biol Chem. 280: 23502–23515. doi:10.1074/jbc.M501163200. PMID 15811851.

Chen, JL; Blasco MA, Greider CW (2000). "Secondary structure of vertebrate telomerase RNA". Cell 100: 503–514. doi:10.1016/S0092-8674(00)80687-X. PMID 10721988.
Antal, M; Boros E, Solymosy F, Kiss T (2002). "Analysis of the structure of human telomerase RNA in vivo". Nucleic Acids Res 30: 912–920. doi:10.1093/nar/30.4.912. PMID 11842102.