VCX

From Wikipedia, the free encyclopedia

Variable charge, X-linked

Identifiers

VCX; MGC118975; VCX-10r; VCX-B1; VCX1; VCX10R; VCXB1; MGC118976; MGC125730; VCX-8r; VCX-A; VCX3; VCX8R; VCXA; MGC119815

External IDs

Gene ontology
Molecular Function:	• chromatin binding • protein binding
Cellular Component:	• nucleus • nucleolus
Biological Process:	• establishment and/or maintenance of chromatin architecture • spermatogenesis • ribosome assembly • nervous system development • brain development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_013452 (mRNA)
NP_038480 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr X: 7.77 - 7.77 Mb

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Pubmed search

[1]

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Variable charge, X-linked, also known as VCX, is a human gene.^[1]

This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.^[1]

[edit] References

^ ^a ^b Entrez Gene: VCX variable charge, X-linked.

[edit] Further reading

Zou SW, Zhang JC, Zhang XD, et al. (2004). "Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis.". Cell Res. 13 (3): 171-7. doi:10.1038/sj.cr.7290161. PMID 12862317.
Sy SM, Wong N, Mok TS, et al. (2003). "Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity.". Lung Cancer 41 (1): 91-9. PMID 12826317.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Fukami M, Kirsch S, Schiller S, et al. (2000). "A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation.". Am. J. Hum. Genet. 67 (3): 563-73. PMID 10903929.
Lahn BT, Page DC (2000). "A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.". Hum. Mol. Genet. 9 (2): 311-9. PMID 10607842.