VAX1

From Wikipedia, the free encyclopedia

Ventral anterior homeobox 1

Identifiers

VAX1; MGC126743; MGC126745

External IDs

OMIM: 604294 MGI: 1277163 HomoloGene: 7593

Gene ontology
Molecular Function:	• transcription factor activity • chromatin DNA binding • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • neuron migration • regulation of transcription, DNA-dependent • multicellular organismal development • negative regulation of neuroblast proliferation • axon guidance • brain development • cell differentiation

Orthologs

Human

Mouse

Refseq

NM_199131 (mRNA)
NP_954582 (protein)

XM_976050 (mRNA)
XP_981144 (protein)

Location

Chr 10: 118.88 - 118.89 Mb

Chr 19: 59.22 - 59.22 Mb

Pubmed search

[1]

[2]

Ventral anterior homeobox 1, also known as VAX1, is a human gene.^[1]

This gene appears to influence the development in humans of the forebrain. It is also present in mice and xenopus frogs, which suggests a long evolutionary history, and in those organisms its expression is confined to the forebrain, optic and olfactory areas.^[2]

[edit] References

^ Entrez Gene: VAX1 ventral anterior homeobox 1.
^ *Hallonet M, Hollemann T, Wehr R, et al. (1998). "Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain.". Development 125 (14): 2599-610. PMID 9636075. pdf

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Barbieri AM, Lupo G, Bulfone A, et al. (1999). "A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis.". Proc. Natl. Acad. Sci. U.S.A. 96 (19): 10729-34. PMID 10485894.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.