Vascular endothelial growth factor B

From Wikipedia, the free encyclopedia

PDB rendering based on 2c7w.

Available structures: 2c7w

Identifiers

Symbol(s)

VEGFB; VEGFL; VRF

External IDs

OMIM: 601398 MGI: 106199 HomoloGene: 2535

Gene ontology
Molecular Function:	• vascular endothelial growth factor receptor binding • protein binding • growth factor activity • heparin binding
Cellular Component:	• extracellular region • membrane
Biological Process:	• regulation of progression through cell cycle • regulation of cell growth • signal transduction • cell proliferation • positive regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001128909 (mRNA)
XP_001128909 (protein)

NM_011697 (mRNA)
NP_035827 (protein)

Location

Chr 11: 63.76 - 63.76 Mb

Chr 19: 7.05 - 7.05 Mb

Pubmed search

[1]

[2]

Vascular endothelial growth factor B is a vascular endothelial growth factor^[1]

[edit] References

^ Entrez Gene: VEGFB vascular endothelial growth factor B.

[edit] Further reading

Joukov V, Kaipainen A, Jeltsch M, et al. (1997). "Vascular endothelial growth factors VEGF-B and VEGF-C.". J. Cell. Physiol. 173 (2): 211-5. doi:10.1002/(SICI)1097-4652(199711)173:2<211::AID-JCP23>3.0.CO;2-H. PMID 9365524.
Olofsson B, Pajusola K, Kaipainen A, et al. (1996). "Vascular endothelial growth factor B, a novel growth factor for endothelial cells.". Proc. Natl. Acad. Sci. U.S.A. 93 (6): 2576-81. PMID 8637916.
Olofsson B, Pajusola K, von Euler G, et al. (1996). "Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform.". J. Biol. Chem. 271 (32): 19310-7. PMID 8702615.
Grimmond S, Lagercrantz J, Drinkwater C, et al. (1996). "Cloning and characterization of a novel human gene related to vascular endothelial growth factor.". Genome Res. 6 (2): 124-31. PMID 8919691.
Olofsson B, Korpelainen E, Pepper MS, et al. (1998). "Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells.". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11709-14. PMID 9751730.
Makinen T, Olofsson B, Karpanen T, et al. (1999). "Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1.". J. Biol. Chem. 274 (30): 21217-22. PMID 10409677.
Ikuta T, Ariga H, Matsumoto K (2001). "Extracellular matrix tenascin-X in combination with vascular endothelial growth factor B enhances endothelial cell proliferation.". Genes Cells 5 (11): 913-927. PMID 11122379.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Qi JH, Ebrahem Q, Moore N, et al. (2003). "A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2.". Nat. Med. 9 (4): 407-15. doi:10.1038/nm846. PMID 12652295.
Trompezinski S, Berthier-Vergnes O, Denis A, et al. (2004). "Comparative expression of vascular endothelial growth factor family members, VEGF-B, -C and -D, by normal human keratinocytes and fibroblasts.". Exp. Dermatol. 13 (2): 98-105. doi:10.1111/j.0906-6705.2004.00137.x. PMID 15009103.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Timoshenko AV, Chakraborty C, Wagner GF, Lala PK (2006). "COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer.". Br. J. Cancer 94 (8): 1154-63. doi:10.1038/sj.bjc.6603067. PMID 16570043.
Iyer S, Scotney PD, Nash AD, Ravi Acharya K (2006). "Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding.". J. Mol. Biol. 359 (1): 76-85. doi:10.1016/j.jmb.2006.03.002. PMID 16616187.
Yamada E, Yamazaki K, Takano K, et al. (2007). "Iodide inhibits vascular endothelial growth factor-A expression in cultured human thyroid follicles: a microarray search for effects of thyrotropin and iodide on angiogenesis factors.". Thyroid 16 (6): 545-54. doi:10.1089/thy.2006.16.545. PMID 16839256.
de Paulis A, Prevete N, Fiorentino I, et al. (2007). "Expression and functions of the vascular endothelial growth factors and their receptors in human basophils.". J. Immunol. 177 (10): 7322-31. PMID 17082651.