Vascular endothelial growth factor A

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PDB rendering based on 1bj1.

Available structures: 1bj1, 1cz8, 1flt, 1kat, 1kmx, 1mjv, 1mkg, 1mkk, 1qty, 1tzh, 1tzi, 1vgh, 1vpf, 1vpp, 2fjg, 2fjh, 2vgh, 2vpf

Identifiers

Symbol(s)

VEGFA; MGC70609; VEGF; VEGF-A; VPF

External IDs

OMIM: 192240 MGI: 103178 HomoloGene: 2534

Gene ontology
Molecular Function:	• vascular endothelial growth factor receptor binding • growth factor activity • heparin binding • protein homodimerization activity • extracellular matrix binding
Cellular Component:	• proteinaceous extracellular matrix • extracellular space • cytoplasm • membrane
Biological Process:	• regulation of progression through cell cycle • angiogenesis • vasculogenesis • response to hypoxia • anti-apoptosis • signal transduction • multicellular organismal development • nervous system development • mesoderm development • cell proliferation • cell migration • lung development • epithelial cell differentiation • positive regulation of vascular endothelial growth factor receptor signaling pathway • eye photoreceptor cell development • positive regulation of epithelial cell proliferation • induction of positive chemotaxis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001025366 (mRNA)
NP_001020537 (protein)

NM_001025250 (mRNA)
NP_001020421 (protein)

Location

Chr 6: 43.85 - 43.86 Mb

Chr 17: 45.48 - 45.5 Mb

Pubmed search

[1]

[2]

Vascular endothelial growth factor A (VEGF-A) is the most important type of Vascular endothelial growth factors. Before the discovery of similar proteins to what now is the VEGF sub-family, VEGF-A was called simply VEGF.

As its name implies, VEGF-A activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g. stimulation monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells ). In vitro, VEGF-A has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF-A is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor.