VAPA

From Wikipedia, the free encyclopedia

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa

PDB rendering based on 1z9l.

Available structures: 1z9l, 1z9o, 2cri

Identifiers

Symbol(s)

VAPA; MGC3745; VAP-33; VAP-A; VAP33; hVAP-33

External IDs

OMIM: 605703 MGI: 1353561 HomoloGene: 37824

Gene ontology
Molecular Function:	• signal transducer activity • structural molecule activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• protein complex assembly • exocytosis • membrane fusion • positive regulation of I-kappaB kinase/NF-kappaB cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003574 (mRNA)
NP_003565 (protein)

NM_013933 (mRNA)
NP_038961 (protein)

Location

Chr 18: 9.9 - 9.95 Mb

Chr 17: 65.48 - 65.51 Mb

Pubmed search

[1]

[2]

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa, also known as VAPA, is a human gene.^[1]

The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa.

[edit] Further reading

Weir ML, Klip A, Trimble WS (1998). "Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP.". Biochem. J. 333 ( Pt 2): 247–51. PMID 9657962.
Nishimura Y, Hayashi M, Inada H, Tanaka T (1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins.". Biochem. Biophys. Res. Commun. 254 (1): 21–6. doi:10.1006/bbrc.1998.9876. PMID 9920726.
Lapierre LA, Tuma PL, Navarre J, et al. (1999). "VAP-33 localizes to both an intracellular vesicle population and with occludin at the tight junction.". J. Cell. Sci. 112 ( Pt 21): 3723–32. PMID 10523508.
Tu H, Gao L, Shi ST, et al. (1999). "Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein.". Virology 263 (1): 30–41. doi:10.1006/viro.1999.9893. PMID 10544080.
Weir ML, Xie H, Klip A, Trimble WS (2001). "VAP-A binds promiscuously to both v- and tSNAREs.". Biochem. Biophys. Res. Commun. 286 (3): 616–21. doi:10.1006/bbrc.2001.5437. PMID 11511104.
Wyles JP, McMaster CR, Ridgway ND (2002). "Vesicle-associated membrane protein-associated protein-A (VAP-A) interacts with the oxysterol-binding protein to modify export from the endoplasmic reticulum.". J. Biol. Chem. 277 (33): 29908–18. doi:10.1074/jbc.M201191200. PMID 12023275.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gao L, Aizaki H, He JW, Lai MM (2004). "Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft.". J. Virol. 78 (7): 3480–8. PMID 15016871.
Evans MJ, Rice CM, Goff SP (2004). "Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication.". Proc. Natl. Acad. Sci. U.S.A. 101 (35): 13038–43. doi:10.1073/pnas.0405152101. PMID 15326295.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Hamamoto I, Nishimura Y, Okamoto T, et al. (2005). "Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B.". J. Virol. 79 (21): 13473–82. doi:10.1128/JVI.79.21.13473-13482.2005. PMID 16227268.
Kawano M, Kumagai K, Nishijima M, Hanada K (2006). "Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT.". J. Biol. Chem. 281 (40): 30279–88. doi:10.1074/jbc.M605032200. PMID 16895911.