Vanillyl-alcohol oxidase

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In enzymology, a vanillyl-alcohol oxidase (EC 1.1.3.38) is an enzyme that catalyzes the chemical reaction

vanillyl alcohol + O₂ $\rightleftharpoons$ vanillin + H₂O₂

Thus, the two substrates of this enzyme are vanillyl alcohol and O₂, whereas its two products are vanillin and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is vanillyl alcohol:oxygen oxidoreductase. This enzyme is also called 4-hydroxy-2-methoxybenzyl alcohol oxidase. This enzyme participates in 2,4-dichlorobenzoate degradation. It employs one cofactor, FAD.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1DZN, 1E0Y, and 1E8G.

[edit] References

IUBMB entry for 1.1.3.38
BRENDA references for 1.1.3.38 (Recommended.)
PubMed references for 1.1.3.38
PubMed Central references for 1.1.3.38
Google Scholar references for 1.1.3.38
de Jong E, van Berkel WJ, van der Zwan RP, de Bont JA (1992). "Purification and characterization of vanillyl-alcohol oxidase from Penicillium simplicissimum. A novel aromatic alcohol oxidase containing covalently bound FAD". Eur. J. Biochem. 208: 651–7. doi:10.1111/j.1432-1033.1992.tb17231.x. PMID 1396672.
Fraaije MW, Veeger C, van Berkel WJ (1995). "Substrate specificity of flavin-dependent vanillyl-alcohol oxidase from Penicillium simplicissimum. Evidence for the production of 4-hydroxycinnamyl alcohols from 4-allylphenols". Eur. J. Biochem. 234: 271–7. doi:10.1111/j.1432-1033.1995.271_c.x. PMID 8529652.