VAMP1

From Wikipedia, the free encyclopedia

Vesicle-associated membrane protein 1 (synaptobrevin 1)

PDB rendering based on 1kil.

Available structures: 1kil, 1n7s

Identifiers

Symbol(s)

VAMP1; DKFZp686H12131; SYB1; VAMP-1

External IDs

OMIM: 185880 MGI: 1313276 HomoloGene: 40678

Gene ontology
Cellular Component:	• mitochondrion • integral to plasma membrane • synaptic vesicle • membrane • integral to membrane • synaptosome • synapse
Biological Process:	• vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014231 (mRNA)
NP_055046 (protein)

NM_001080557 (mRNA)
NP_001074026 (protein)

Location

Chr 12: 6.44 - 6.45 Mb

Chr 6: 125.18 - 125.21 Mb

Pubmed search

[1]

[2]

Vesicle-associated membrane protein 1 (synaptobrevin 1), also known as VAMP1, is a human gene.^[1]

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined.^[1]

[edit] References

^ ^a ^b Entrez Gene: VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1).

[edit] Further reading

Archer BT, Ozçelik T, Jahn R, et al. (1990). "Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2.". J. Biol. Chem. 265 (28): 17267–73. PMID 1976629.
Ravichandran V, Chawla A, Roche PA (1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues.". J. Biol. Chem. 271 (23): 13300–3. PMID 8663154.
Jagadish MN, Fernandez CS, Hewish DR, et al. (1996). "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.". Biochem. J. 317 ( Pt 3): 945–54. PMID 8760387.
Annaert WG, Becker B, Kistner U, et al. (1998). "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31.". J. Cell Biol. 139 (6): 1397–410. PMID 9396746.
Weir ML, Klip A, Trimble WS (1998). "Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP.". Biochem. J. 333 ( Pt 2): 247–51. PMID 9657962.
Isenmann S, Khew-Goodall Y, Gamble J, et al. (1999). "A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal.". Mol. Biol. Cell 9 (7): 1649–60. PMID 9658161.
Nishimura Y, Hayashi M, Inada H, Tanaka T (1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins.". Biochem. Biophys. Res. Commun. 254 (1): 21–6. doi:10.1006/bbrc.1998.9876. PMID 9920726.
Berglund L, Hoffmann HJ, Dahl R, Petersen TE (1999). "VAMP-1 has a highly variable C-terminus generated by alternative splicing.". Biochem. Biophys. Res. Commun. 264 (3): 777–80. doi:10.1006/bbrc.1999.1588. PMID 10544008.
Pérez-Brangulí F, Muhaisen A, Blasi J (2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay.". Mol. Cell. Neurosci. 20 (2): 169–80. PMID 12093152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.". Exp. Cell Res. 288 (1): 35–50. PMID 12878157.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.