Valosin-containing protein

From Wikipedia, the free encyclopedia

PDB rendering based on 1e32.

Available structures: 1e32, 1oz4, 1r7r, 1s3s, 1ypw, 1yq0, 1yqi, 2pjh

Identifiers

Symbol(s)

VCP; p97; IBMPFD; MGC131997; MGC148092; MGC8560; TERA

External IDs

OMIM: 601023 MGI: 99919 HomoloGene: 5168

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • ATP binding • lipid binding • hydrolase activity • ATPase activity
Cellular Component:	• nucleus • endoplasmic reticulum • microsome • cytosol
Biological Process:	• double-strand break repair • transport • caspase activation • protein ubiquitination • ER-associated protein catabolic process • unfolded protein response • retrograde protein transport, ER to cytosol • regulation of apoptosis • establishment of protein localization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_007126 (mRNA)
NP_009057 (protein)

NM_009503 (mRNA)
NP_033529 (protein)

Location

Chr 9: 35.05 - 35.06 Mb

n/a

Pubmed search

[1]

[2]

Valosin-containing protein, also known as VCP, is a human gene.^[1]

Valosin-containing protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.^[1]

[edit] References

^ ^a ^b Entrez Gene: VCP valosin-containing protein.

[edit] Further reading

Guinto JB, Ritson GP, Taylor JP, Forman MS (2007). "Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy.". Acta Neuropathol. 114 (1): 55–61. doi:10.1007/s00401-007-0224-7. PMID 17457594.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. PMID 1602151.
Rabouille C, Levine TP, Peters JM, Warren G (1995). "An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments.". Cell 82 (6): 905–14. PMID 7553851.
Pleasure IT, Black MM, Keen JH (1993). "Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein.". Nature 365 (6445): 459–62. doi:10.1038/365459a0. PMID 8413590.
Druck T, Gu Y, Prabhala G, et al. (1996). "Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP.". Genomics 30 (1): 94–7. doi:10.1006/geno.1995.0016. PMID 8595912.
Germain-Lee EL, Obie C, Valle D (1997). "NVL: a new member of the AAA family of ATPases localized to the nucleus.". Genomics 44 (1): 22–34. doi:10.1006/geno.1997.4856. PMID 9286697.
Hoyle J, Tan KH, Fisher EM (1997). "Mapping the valosin-containing protein (VCP) gene on human chromosome 9 and mouse chromosome 4, and a likely pseudogene on the mouse X chromosome.". Mamm. Genome 8 (10): 778–80. PMID 9321476.
Dai RM, Chen E, Longo DL, et al. (1998). "Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha.". J. Biol. Chem. 273 (6): 3562–73. PMID 9452483.
Rabouille C, Kondo H, Newman R, et al. (1998). "Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro.". Cell 92 (5): 603–10. PMID 9506515.
Zhang SH, Liu J, Kobayashi R, Tonks NK (1999). "Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1.". J. Biol. Chem. 274 (25): 17806–12. PMID 10364224.
Zhang H, Wang Q, Kajino K, Greene MI (2000). "VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells.". DNA Cell Biol. 19 (5): 253–63. doi:10.1089/10445490050021168. PMID 10855792.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.
Lavoie C, Chevet E, Roy L, et al. (2001). "Tyrosine phosphorylation of p97 regulates transitional endoplasmic reticulum assembly in vitro.". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13637–42. doi:10.1073/pnas.240278097. PMID 11087817.
Kimonis VE, Kovach MJ, Waggoner B, et al. (2001). "Clinical and molecular studies in a unique family with autosomal dominant limb-girdle muscular dystrophy and Paget disease of bone.". Genet. Med. 2 (4): 232–41. PMID 11252708.
Seigneurin-Berny D, Verdel A, Curtet S, et al. (2001). "Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways.". Mol. Cell. Biol. 21 (23): 8035–44. doi:10.1128/MCB.21.23.8035-8044.2001. PMID 11689694.
Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol.". Arch. Biochem. Biophys. 400 (1): 105–10. doi:10.1006/abbi.2002.2778. PMID 11913976.
Asai T, Tomita Y, Nakatsuka S, et al. (2002). "VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line.". Jpn. J. Cancer Res. 93 (3): 296–304. PMID 11927012.
Kobayashi T, Tanaka K, Inoue K, Kakizuka A (2003). "Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells.". J. Biol. Chem. 277 (49): 47358–65. doi:10.1074/jbc.M207783200. PMID 12351637.
Uchiyama K, Jokitalo E, Kano F, et al. (2003). "VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo.". J. Cell Biol. 159 (5): 855–66. doi:10.1083/jcb.200208112. PMID 12473691.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.