Valine-pyruvate transaminase

From Wikipedia, the free encyclopedia

In enzymology, a valine-pyruvate transaminase (EC 2.6.1.66) is an enzyme that catalyzes the chemical reaction

L-valine + pyruvate 3-methyl-2-oxobutanoate + L-alanine

Thus, the two substrates of this enzyme are L-valine and pyruvate, whereas its two products are 3-methyl-2-oxobutanoate and L-alanine.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-valine:pyruvate aminotransferase. Other names in common use include transaminase C, valine-pyruvate aminotransferase, and alanine-oxoisovalerate aminotransferase. This enzyme participates in valine, leucine and isoleucine biosynthesis.

[edit] References

• IUBMB entry for 2.6.1.66
• BRENDA references for 2.6.1.66 (Recommended.)
• PubMed references for 2.6.1.66
• PubMed Central references for 2.6.1.66
• Google Scholar references for 2.6.1.66
• Falkinham JO 3rd (1979). "Identification of a mutation affecting an alanine-alpha-ketoisovalerate transaminase activity in Escherichia coli K-12". Mol. Gen. Genet. 176: 147–9. doi:10.1007/BF00334306. PMID 396446. 
• RUDMAN D, MEISTER A (1953). "Transamination in Escherichia coli". J. Biol. Chem. 200: 591–604. PMID 13034817. 

[edit] External links

The CAS registry number for this enzyme class is 132421-38-6.

• IUBMB entry for 2.6.1.66

• KEGG entry for 2.6.1.66

• BRENDA entry for 2.6.1.66

• NiceZyme view of 2.6.1.66

• EC2PDB: PDB structures for 2.6.1.66

• PRIAM entry for 2.6.1.66

• PUMA2 entry for 2.6.1.66

• IntEnz: Integrated Enzyme entry for 2.6.1.66

• MetaCyc entry for 2.6.1.66

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0009042: valine-pyruvate transaminase

• AMIGO entry for GO code 0009042: valine-pyruvate transaminase