VA RNA

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VA RNA
Template:Abbreviation
Type: Gene;
2° structure: Published; PubMed, Moxon SJ
Seed alignment: Bateman A, Moxon SJ
Avg length: 158.9 nucleotides
Avg identity: 70%

The VA (viral associated) RNA is a non-coding RNA found in adenovirus.[1][2] It plays a role in regulating translation. [3] There are two copies of this RNA called VAI or VA RNAI and VAII or VA RNAII.

Contents

[edit] Function

VAI stimulates the translation of both early and late viral genes including E3 and hexon. [4] VAII does not stimulate translation. VAI increases the stability of additionally ribosome bound RNAs using a transient transfection assay. [5]

VAI RNA is processed in the cell to create 22 nucleotide long RNAs that can act as siRNA or miRNA. [6] VAI RNA functions as a decoy RNA for the double stranded RNA activated protein kinase R which would otherwise phosphorylate eukaryotic initiation factor 2.

[edit] Structure

VA RNA is composed of two stem-loops separated by a central region essential for function. [7]

[edit] References

  1. ^ Mathews, MB (1995). "Structure, function, and evolution of adenovirus virus-associated RNAs". Curr Top Microbiol Immunol 199: 173–187. PMID 7555067. 
  2. ^ Kidd, AH; Garwicz D, Oberg M (1995). "Human and simian adenoviruses: phylogenetic inferences from analysis of VA RNA genes". Virology 207: 32–45. doi:10.1006/viro.1995.1049. PMID 95176559. 
  3. ^ Thimmappaya, B; Weinberger C, Schneider RJ, Shenk T (1982). "Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection". Cell 31: 543–551. doi:10.1016/0092-8674(82)90310-5. PMID 6297772. 
  4. ^ Svensson, C; Akusjarvi G (1984). "Adenovirus VA RNAI: a positive regulator of mRNA translation". Mol Cell Biol 4: 736–742. PMID 6201722. 
  5. ^ Strijker, R; Fritz DT, Levinson AD (1989). "Adenovirus VAI-RNA regulates gene expression by controlling stability of ribosome-bound RNAs". EMBO J 8: 2669–2675. PMID 2583126. 
  6. ^ Sano M, Kato Y, Taira K (2006). "Sequence-specific interference by small RNAs derived from adenovirus VAI RNA". FEBS Lett. 580 (6): 1553–64. doi:10.1016/j.febslet.2006.01.085. PMID 16472808. 
  7. ^ Ma, Y; Mathews MB (1996). "Secondary and tertiary structure in the central domain of adenovirus type 2 VA RNA I". RNA 2: 937–951. PMID 8809020. 

[edit] External links


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