UXT

From Wikipedia, the free encyclopedia

Ubiquitously-expressed transcript

Identifiers

UXT; ART-27

External IDs

OMIM: 300234 MGI: 1277988 HomoloGene: 40902

Gene ontology
Molecular Function:	• protein binding • microtubule binding • beta-tubulin binding • actin filament binding
Cellular Component:	• gamma-tubulin complex • nucleus • centrosome • cytoskeleton • prefoldin complex
Biological Process:	• microtubule cytoskeleton organization and biogenesis • protein folding • mitochondrion transport along microtubule • centrosome organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004182 (mRNA)
NP_004173 (protein)

NM_013840 (mRNA)
NP_038868 (protein)

Location

Chr X: 47.4 - 47.4 Mb

Chr X: 20.11 - 20.12 Mb

Pubmed search

[1]

[2]

Ubiquitously-expressed transcript, also known as UXT, is a human gene.^[1]

This gene encodes a novel protein which is highly conserved in mouse. It interacts with the N-terminus of the androgen receptor and plays a role in facilitating receptor-induced transcriptional activation. It is also likely to be involved in tumorigenesis as it is abundantly expressed in tumor tissues. This gene is part of a gene cluster on chromosome Xp11.23. Alternative splicing results in 2 transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: UXT ubiquitously-expressed transcript.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Schroer A, Schneider S, Ropers H, Nothwang H (1999). "Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue.". Genomics 56 (3): 340–3. PMID 10087202.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis.". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMID 11799066.
Liu L, McKeehan WL (2002). "Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity.". Genomics 79 (1): 124–36. doi:10.1006/geno.2001.6679. PMID 11827465.
Markus SM, Taneja SS, Logan SK, et al. (2002). "Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus.". Mol. Biol. Cell 13 (2): 670–82. doi:10.1091/mbc.01-10-0513. PMID 11854421.
Thiselton DL, McDowall J, Brandau O, et al. (2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders.". Genomics 79 (4): 560–72. doi:10.1006/geno.2002.6733. PMID 11944989.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Liu L, Amy V, Liu G, McKeehan WL (2003). "Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells.". In Vitro Cell. Dev. Biol. Anim. 38 (10): 582–94. PMID 12762840.
Gstaiger M, Luke B, Hess D, et al. (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.". Science 302 (5648): 1208–12. doi:10.1126/science.1088401. PMID 14615539.
Rayala HJ, Kendirgi F, Barry DM, et al. (2004). "The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155.". Mol. Cell Proteomics 3 (2): 145–55. doi:10.1074/mcp.M300106-MCP200. PMID 14645504.
Taneja SS, Ha S, Swenson NK, et al. (2004). "ART-27, an androgen receptor coactivator regulated in prostate development and cancer.". J. Biol. Chem. 279 (14): 13944–52. doi:10.1074/jbc.M306576200. PMID 14711828.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Zhao H, Wang Q, Zhang H, et al. (2006). "UXT is a novel centrosomal protein essential for cell viability.". Mol. Biol. Cell 16 (12): 5857–65. doi:10.1091/mbc.E05-08-0705. PMID 16221885.
Moss TN, Vo A, McKeehan WL, Liu L (2007). "UXT (Ubiquitously Expressed Transcript) causes mitochondrial aggregation.". In Vitro Cell. Dev. Biol. Anim. 43 (3-4): 139–46. doi:10.1007/s11626-007-9016-6. PMID 17554592.
Sun S, Tang Y, Lou X, et al. (2007). "UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome.". J. Cell Biol. 178 (2): 231–44. doi:10.1083/jcb.200611081. PMID 17620405.