UVRAG

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UV radiation resistance associated gene
Identifiers
Symbol(s) UVRAG; DHTX; p63
External IDs OMIM: 602493 MGI: 1925860 HomoloGene: 31150
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7405 78610
Ensembl ENSG00000198382 ENSMUSG00000035354
Uniprot Q9P2Y5 n/a
Refseq NM_003369 (mRNA)
NP_003360 (protein)		 NM_178635 (mRNA)
NP_848750 (protein)
Location Chr 11: 75.2 - 75.53 Mb Chr 7: 98.76 - 99.02 Mb
Pubmed search [1] [2]

UV radiation resistance associated gene, also known as UVRAG, is a human gene.[1]

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.[1]

[edit] References

  1. ^ a b Entrez Gene: UVRAG UV radiation resistance associated gene.

[edit] Further reading

  • Liang C, Feng P, Ku B, et al. (2007). "UVRAG: a new player in autophagy and tumor cell growth.". Autophagy 3 (1): 69–71. PMID 17106237. 
  • Teitz T, Penner M, Eli D, et al. (1990). "Isolation by polymerase chain reaction of a cDNA whose product partially complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells.". Gene 87 (2): 295–8. PMID 2332174. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Perelman B, Dafni N, Naiman T, et al. (1997). "Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus.". Genomics 41 (3): 397–405. doi:10.1006/geno.1997.4623. PMID 9169138. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Bekri S, Adélaïde J, Merscher S, et al. (1998). "Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma.". Cytogenet. Cell Genet. 79 (1-2): 125–31. PMID 9533029. 
  • Iida A, Emi M, Matsuoka R, et al. (2000). "Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation.". Hum. Genet. 106 (3): 277–87. PMID 10798355. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Goi T, Kawasaki M, Yamazaki T, et al. (2004). "Ascending colon cancer with hepatic metastasis and cholecystolithiasis in a patient with situs inversus totalis without any expression of UVRAG mRNA: report of a case.". Surg. Today 33 (9): 702–6. doi:10.1007/s00595-002-2567-y. PMID 12928850. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Ionov Y, Nowak N, Perucho M, et al. (2004). "Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability.". Oncogene 23 (3): 639–45. doi:10.1038/sj.onc.1207178. PMID 14737099. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Liang C, Feng P, Ku B, et al. (2006). "Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.". Nat. Cell Biol. 8 (7): 688–99. doi:10.1038/ncb1426. PMID 16799551. 
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